Predicting disease progression in behavioral variant frontotemporal dementia

被引：7

作者：

Anderl-Straub, Sarah ^{[1
]}

Lausser, Ludwig ^{[2
]}

Lombardi, Jolina ^{[1
]}

Uttner, Ingo ^{[1
]}

Fassbender, Klaus ^{[3
]}

Fliessbach, Klaus ^{[4
]}

Huppertz, Hans-Jurgen ^{[5
]}

Jahn, Holger ^{[6
]}

Kornhuber, Johannes ^{[7
]}

Obrig, Hellmuth ^{[8
,9
]}

Schneider, Anja ^{[4
,10
]}

Semler, Elisa ^{[1
]}

Synofzik, Matthis ^{[11
,12
,13
]}

Danek, Adrian ^{[14
]}

Prudlo, Johannes ^{[15
,16
]}

Kassubek, Jan ^{[1
]}

Landwehrmeyer, Bernhard ^{[1
]}

Lauer, Martin ^{[17
]}

Volk, Alexander E. ^{[18
]}

Wiltfang, Jens ^{[19
,20
,21
]}

Diehl-Schmid, Janine ^{[22
]}

Ludolph, Albert C. ^{[1
]}

Schroeter, Matthias L. ^{[8
,9
]}

Kestler, Hans A. ^{[2
]}

Otto, Markus ^{[1
,23
]}

机构：

[1] Univ Ulm, Dept Neurol, Ulm, Germany

[2] Univ Ulm, Inst Med Syst Biol, Ulm, Germany

[3] Saarland Univ, Dept Neurol, Homburg, Germany

[4] Univ Hosp Bonn, Clin Neurodegenerat Dis & Geriatr Psychiat, Bonn, Germany

[5] Swiss Epilepsy Clin, Zurich, Switzerland

[6] Univ Hosp Hamburg Eppendorf, Dept Psychiat & Psychotherapy, Hamburg, Germany

[7] Univ Erlangen Nurnberg, Dept Psychiat & Psychotherapy, Erlangen, Germany

[8] Univ Hosp Leipzig, Max Planck Inst Human Cognit & Brain Sci, Leipzig, Germany

[9] Univ Hosp Leipzig, Clin Cognit Neurol, Leipzig, Germany

[10] German Ctr Neurodegenerat Dis DZNE, Bonn, Germany

[11] Univ Tubingen, Ctr Neurol, Dept Neurodegenerat Dis, Tubingen, Germany

[12] Univ Tubingen, Hertie Inst Clin Brain Res, Tubingen, Germany

[13] German Ctr Neurodegenerat Dis DZNE, Tubingen, Germany

[14] Ludwig Maximilians Univ Munchen, Dept Neurol, Munich, Germany

[15] Rostock Univ, Med Ctr, Dept Neurol, Rostock, Germany

[16] German Ctr Neurodegenerat Dis DZNE, Rostock, Germany

[17] Univ Wurzburg, Dept Psychiat & Psychotherapy, Wurzburg, Germany

[18] Univ Hosp Hamburg Eppendorf, Inst Human Genet, Hamburg, Germany

[19] Univ Med Ctr Gottingen UMG, Dept Psychiat & Psychotherapy, Gottingen, Germany

[20] German Ctr Neurodegenerat Dis DZNE, Gottingen, Germany

[21] Univ Aveiro, Inst Biomed iBiMED, Dept Med Sci, Neurosci & Signaling Grp, Aveiro, Portugal

[22] Tech Univ Munich, Dept Psychiat & Psychotherapy, Munich, Germany

[23] Martin Luther Univ Hal Wittenberg, Univ Clin Halle, Dept Neurol, Halle, Saale, Germany

来源：

ALZHEIMER'S & DEMENTIA: DIAGNOSIS, ASSESSMENT & DISEASE MONITORING | 2021年 / 13卷 / 01期

关键词：

behavioral variant frontotemporal dementia; brain volume; classification models; disease progression; frontotemporal dementia; prognosis; DISTINCT SUBTYPES; INSIGHTS; CORTEX; REWARD;

D O I：

10.1002/dad2.12262

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Introduction The behavioral variant of frontotemporal dementia (bvFTD) is a rare neurodegenerative disease. Reliable predictors of disease progression have not been sufficiently identified. We investigated multivariate magnetic resonance imaging (MRI) biomarker profiles for their predictive value of individual decline. Methods One hundred five bvFTD patients were recruited from the German frontotemporal lobar degeneration (FTLD) consortium study. After defining two groups ("fast progressors" vs. "slow progressors"), we investigated the predictive value of MR brain volumes for disease progression rates performing exhaustive screenings with multivariate classification models. Results We identified areas that predict disease progression rate within 1 year. Prediction measures revealed an overall accuracy of 80% across our 50 top classification models. Especially the pallidum, middle temporal gyrus, inferior frontal gyrus, cingulate gyrus, middle orbitofrontal gyrus, and insula occurred in these models. Discussion Based on the revealed marker combinations an individual prognosis seems to be feasible. This might be used in clinical studies on an individualized progression model.

引用

页数：11

共 36 条

[1] The von Economo neurons in the frontoinsular and anterior cingulate cortex [J].