Cytotoxic potency of self-assembled Ruthenium(H)-NHC complexes with pincer type 2, 6-bis(N-methylimidazolylidene/benzimidazolylidene)pyrazine ligands

被引：19

作者：

Roymahapatra, Gourisannkar ^{[1
,2
,3
]}

Dinda, Joydev ^{[2
,4
]}

Mishra, Anjan ^{[2
]}

Mahapatra, Ambikesh ^{[3
]}

Hwang, Wen-Shu ^{[5
]}

Mandal, Santi M. ^{[6
]}

机构：

[1] Global Inst Sci & Technol, Dept Basic Sci & Humanities, Haldia, India

[2] Haldia Inst Technol, Sch Appl Sci, Haldia, India

[3] Jadavpur Univ, Dept Chem, Kolkata, India

[4] Inst Technol & Management Univ, Dept Chem, Gwalior, India

[5] Natl Dong Hwa Univ, Dept Chem, Hualion, Taiwan

[6] Indian Inst Technol, Cent Res Facil, Kharagpur 721302, W Bengal, India

来源：

JOURNAL OF CANCER RESEARCH AND THERAPEUTICS | 2015年 / 11卷 / 01期

关键词：

Antimicrobial; DNA binding; NHC; Ruthenium (II)-NHC complex; Nanoball; pro-apoptotic; HETEROCYCLIC CARBENES; PALLADIUM; ANTICANCER; CATALYSTS;

D O I：

10.4103/0973-1482.150416

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Objective: To study the cytotoxic potency of self-assembled Ruthenium(II)-NHC complexes with 2,6-di-(N-methylimidazolylidene/benzimidazolylidene)pyrazine ligands. Materials and Methods: Ru(II)-N-heterocyclic (Ru-NHC) complexes, Bis-[2,6-di-(N-methylimidazol-2-ylidene)pyrazine]ruthenium(11) hexaflurophosphate (3), Bis-[2,6-di-(N-methylbenzimidazol-2-ylidene)pyrazine]ruthenium(11) hexaflurophosphate (4) have been synthesized from corresponding ligands 2,6-di-(N-methylimidazolium)pyrazine dichloride (1); 2,6-di-(N-methylbenzimidazolium) pyrazine dichloride (2). Complexes were studied to determine their pro-apoptotic activity against HCT15 and Hep2 cell lines, and antimicrobial activity against Pseudomonas aeruginosa, Staphylococcus epidermidis and Candida albicans. Results: Both, complex 3 and 4, formed a nanosphere structure in aqueous growth medium. Cytotoxicity study revealed that complex 3 was more effective than complex 4. Complexes mainly target cellular DNA and bacterial cell wall. Conclusion: This is the first report on the formation of nanoball structure of Ru(II)-NHC complexes. Thus, complex 3 provides a new insight to develop antitumor or antimicrobial drug.

引用

页码：105 / +

页数：9

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