Novel cytotoxic monotetrahydrofuranic annonaceous acetogenins from Annona montana

被引：36
|
作者：
Liaw, CC
Chang, FR
Chen, SL
Wu, CC
Lee, KH
Wu, YC
机构：
[1] Kaohsiung Med Univ, Grad Inst Nat Prod, Kaohsiung, Taiwan
[2] Univ N Carolina, Sch Pharm, Nat Prod Lab, Chapel Hill, NC 27599 USA
来源：
BIOORGANIC & MEDICINAL CHEMISTRY | 2005年 / 13卷 / 15期
关键词：
annonaceous acetogenin; Annona montana; linear acetogenin; cytotoxicity; Hep G2;
D O I：
10.1016/j.bmc.2005.05.008
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Four new monotetrahydrofuranic Annonaceous acetogenins, montalicins G (1) and H (2) and monlicins A (3) and B (4), and two new linear acetogenins, (+)-monhexocin (5) and (-)-monhexocin (6), as well as three known compounds, murisolin (7), 4-deoxyannomontacin (8), and muricatacin (9), were isolated from the seeds of Annona montana by high performance liquid chromatographic (HPLC) method. The absolute stereochemical structures of new isolates were elucidated and characterized by spectral and chemical methods. Interestingly, these compounds show special cytotoxicity against human hepatoma cells, Hep G2. (c) 2005 Elsevier Ltd. All rights reserved.
引用
收藏
页码：4767 / 4776
页数：10
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