Fun with radicals: Some new perspectives for organic synthesis

被引:185
作者
Quiclet-Sire, Beatrice [1 ]
Zard, Samir Z. [1 ]
机构
[1] Ecole Polytech, CNRS, Organ Synth Lab, UMR 7652, F-91128 Palaiseau, France
关键词
aromatics; heteroaromatics; heterocycles; radical additions; RAFT-MADIX controlled polymerization; total synthesis; xanthates; INTERMOLECULAR ADDITIONS; UNEXPECTED SYNTHESIS; CONVERGENT APPROACH; XANTHIC ANHYDRIDES; CARBAMOYL RADICALS; CONVENIENT SOURCE; FORMAL SYNTHESIS; ALKYL XANTHATES; NITROGEN BONDS; CHAIN-REACTION;
D O I
10.1351/PAC-CON-10-08-07
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
The degenerative radical addition-transfer of xanthates onto alkenes allows the rapid assembly of richly functionalized structures. Various families of open-chain, cyclic, and polycyclic compounds can thus be readily accessed. Furthermore, the process can be extended to the synthesis or modification of aromatic and heteroaromatic derivatives by exploiting the possibility of using peroxides both as initiators and stoichiometric oxidants. The modification of existing polymers and the controlled synthesis of block polymers by what is now known as the RAFT/MADIX (reversible addition-fragmentation transfer/macro-molecular design by interchange of xanthate) process is described briefly.
引用
收藏
页码:519 / 551
页数:33
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