Gloeophyllins A-J, Cytotoxic Ergosteroids with Various Skeletons from a Chinese Tibet Fungus Gloeophyllum abietinum

被引：32

作者：

Han, Jun-Jie ^{[1
]}

Bao, Li ^{[1
]}

Tao, Qiao-Qiao ^{[1
]}

Yao, Yi-Jian ^{[1
]}

Liu, Xing-Zhong ^{[1
]}

Yin, Wen-Bing ^{[1
]}

Liu, Hong-Wei ^{[1
]}

机构：

[1] Chinese Acad Sci, Inst Microbiol, State Key Lab Mycol, Beijing 100101, Peoples R China

来源：

ORGANIC LETTERS | 2015年 / 17卷 / 10期

基金：

中国国家自然科学基金;

关键词：

STEROIDAL ALKALOIDS; OOSPONOL; SPONGE;

D O I：

10.1021/acs.orglett.5b01080

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Ten new ergosteroids, gloeophyllins A-J (1-10), have been isolated from the solid cultures of Gloeophyllum abietinum. The absolute configurations of 1, 2, and 9 were determined by X-ray crystallographic analysis. Compound 1 has a rare C-nor-D-homosteroid skeleton. Compound 9 possesses an unusual ergostane skeleton having a 10-oxabicyclo [4.3,1] decane moiety replacing 6/5 fused C/D rings. Compound 10 represents the first ergosteroid featuring the cleavage of a C8-C14 bond. The Cytotoxicity of 1-10 Was tested against the human cancer cell lines K562 and HCT116. The biosynthetic pathway for 1-10 is postulated.

引用

页码：2538 / 2541

页数：4

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