Cell-surface adhesive interactions in microchannels and microvessels

被引：6

作者：

King, MR ^{[1
]}

机构：

[1] Univ Rochester, Dept Biomed Engn, Rochester, NY 14642 USA

来源：

MICROSCALE THERMOPHYSICAL ENGINEERING | 2005年 / 9卷 / 03期

基金：

美国国家卫生研究院;

关键词：

multiparticle adhesive dynamics; selectin; leukocyte; cell adhesion; microchannel;

D O I：

10.1080/10893950500196295

中图分类号：

O414.1 [热力学];

学科分类号：

摘要：

Adhesive interactions between white blood cells and the interior surface of the blood vessels they contact is important in inflammation and in the progression of heart disease. Parallel-plate microchannels have been useful in characterizing the strength of these interactions, in conditions that are much simplified over the complex environment these cells experience in the body. Recent computational and experimental work by several laboratories have attempted to bridge this gap between behavior observed inflow chamber experiments and cell-surface interactions observed in the microvessels of anesthetized animals.

引用

页码：255 / 264

页数：10

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