Objectives: We reviewed the literature on IV stroke thrombolysis for patients with recent myocardial infarction (MI). Methods: We searched PubMed and Ovid databases, relevant trials, and guidelines. Results: Only 5 thrombolyzed stroke patients with recent MI were reported to have cardiac tamponade. Pathological studies show MI healing is completed by 7 weeks. Conclusion: The time window from MI as a contraindication for IV stroke thrombolysis may be narrowed from 3 months in current guidelines to 7 weeks. Neurology (R) 2011;76:1838-1840