Exploiting the Physicochemical and Antimicrobial Properties of PHB/PEG and PHB/PEG/ALG-e Blends Loaded with Ag Nanoparticles

被引：11

作者：

da Silva, Mario R. P. ^{[1
]}

Matos, Robert S. ^{[1
]}

Monteiro, Michael D. S. ^{[2
]}

Santos, Samuel B. ^{[3
]}

Filho, Henrique D. F. ^{[4
]}

Andrade, George R. S. ^{[5
]}

Salerno, Marco ^{[6
]}

Almeida, Luis E. ^{[1
]}

机构：

[1] Fed Univ Sergipe UFS, PostGrad Program Mat Sci & Engn, BR-49100000 Sao Cristovao, Sergipe, Brazil

[2] Univ Fed Sergipe, Lab Corros & Nanotechnol LCNT, BR-49100000 Sao Cristovao, Sergipe, Brazil

[3] Fed Univ Sergipe UFS, PostGrad Program Physiol Sci, BR-49100000 Sao Cristovao, Sergipe, Brazil

[4] Fed Univ Amazonas UFAM, Lab Synth Nanomat & Nanoscopy LSNN, BR-69077000 Manaus, Amazonas, Brazil

[5] Univ Fed Espirito Santo, PostGrad Program Energy, BR-29075910 Sao Mateus, Espirito Santo, Brazil

[6] Tech Univ Dresden, Inst Globally Distributed Open Res & Educ IGDORE, Inst Mat Sci, Max Bergmann Ctr Biomat, D-01069 Dresden, Germany

来源：

MATERIALS | 2022年 / 15卷 / 21期

关键词：

poly(3-hydroxybutyrate); polyethylene glycol; esterified alginate; nanocomposites; antibacterial activity; COATED SILVER NANOPARTICLES; ANTIBACTERIAL PROPERTIES; ALGINATE; FILMS; POLY(3-HYDROXYBUTYRATE); CELLULOSE; PHB; NANOCOMPOSITES; CRYSTALLIZATION; BIOSYNTHESIS;

D O I：

10.3390/ma15217544

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

Poly(3-hydroxybutyrate) (PHB)-based films containing Poly(ethylene glycol) (PEG), esterified sodium alginate (ALG-e) and polymeric additives loaded with Ag nanoparticles (AgNPs) were obtained by a conventional casting method. AgNPs were produced in aqueous suspension and added to polymeric gels using a phase exchange technique. Composite formation was confirmed by finding the Ag peak in the XRD pattern of PHB. The morphological analysis showed that the inclusion of PEG polymer caused the occurrence of pores over the film surface, which were overshadowed by the addition of ALG-e polymer. The PHB functional groups were dominating the FTIR spectrum, whose bands associated with the crystalline and amorphous regions increased after the addition of PEG and ALG-e polymers. Thermal analysis of the films revealed a decrease in the degradation temperature of PHB containing PEG/AgNPs and PEG/ALG-e/AgNPs, suggesting a catalytic effect. The PHB/PEG/ALG-e/AgNPs film combined the best properties of water vapor permeability and hydrophilicity of the different polymers used. All samples showed good antimicrobial activity in vitro, with the greater inhibitory halo observed for the PEG/PEG/AgNPs against Gram positive S. aureus microorganisms. Thus, the PHB/PEG/ALG-e/AgNPs composite demonstrated here is a promising candidate for skin wound healing treatment.

引用

页数：18

共 72 条

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