Genetic Risk Evaluation in Wet Age-Related Macular Degeneration Treatment Response

被引：9

作者：

Chaudhary, Varun ^{[1
]}

Brent, Michael ^{[2
]}

Lam, Wai-Ching ^{[2
]}

Devenyi, Robert ^{[2
]}

Teichman, Joshua ^{[1
]}

Mak, Michael ^{[2
]}

Barbosa, Joshua ^{[1
]}

Kaur, Harneel ^{[1
]}

Carter, Ronald ^{[4
]}

Farrokhyar, Forough ^{[3
]}

机构：

[1] McMaster Univ, St Josephs Healthcare Hamilton, Hamilton Reg Eye Inst, Div Ophthalmol,Dept Surg, Hamilton, ON, Canada

[2] Univ Toronto, Dept Ophthalmol & Vis Sci, Toronto, ON, Canada

[3] McMaster Univ, Dept Surg, Hamilton, ON, Canada

[4] McMaster Univ, Dept Pathol & Mol Med, Hamilton, ON, Canada

来源：

OPHTHALMOLOGICA | 2016年 / 236卷 / 02期

关键词：

Genetics; Visual acuity; Age-related macular degeneration; RANIBIZUMAB TREATMENT; CFH; POLYMORPHISM; DELETION; VARIANT; Y402H; PHARMACOGENETICS; SUSCEPTIBILITY; ASSOCIATION; THERAPY;

D O I：

10.1159/000446819

中图分类号：

R77 [眼科学];

学科分类号：

100212 ;

摘要：

Objective: To evaluate the pharmacogenetic relationship between CFH haplotypes and single nucleotide polymorphisms (SNPs) with response to ranibizumab treatment for neovascular age-related macular degeneration (nAMD). Patients and Methods: This was a prospective cohort study involving 70 treatment-naive nAMD patients. Patients were genotyped for CFH haplotypes and SNPs in the C3, ARMS2, and mtDNA genes. Visual acuity and central macular thickness were assessed at baseline and during 6 monthly follow-up visits. Multivariate logistic regression was used to determine the association between genotypes and a gain of >= 15 letters at the 6-month endpoint after adjusting for potential confounders. Results: CFH haplotypes were associated with a gain of letters at the 6-month endpoint (p = 0.046). Patients expressing protective haplotypes were more likely to achieve a gain of >= 15 letters relative to the greatly increased risk haplotypes [OR 6.58 (95% CI: 1.37, 31.59)]. Conclusion: CFH is implicated in nAMD patient treatment response to ranibizumab. (C) 2016 S. Karger AG, Basel

引用

页码：88 / 94

页数：7

共 23 条

[1] Mitochondrial DNA Polymorphism A4917G Is Independently Associated with Age-Related Macular Degeneration [J].