Functional analyses of the stratum corneum in scars - Sequential studies after injury and comparison among keloids, hypertrophic scars, and atrophic scars

被引:96
作者
Suetake, T [1 ]
Sasai, S [1 ]
Zhen, YX [1 ]
Ohi, T [1 ]
Tagami, H [1 ]
机构
[1] TOHOKU UNIV, SCH MED, DEPT DERMATOL, AOBA KU, SENDAI, MIYAGI 98077, JAPAN
关键词
D O I
10.1001/archderm.132.12.1453
中图分类号
R75 [皮肤病学与性病学];
学科分类号
100206 ;
摘要
Objective: To characterize the functional properties of the stratum corneum (SC) of various scars. Design: A prospective cohort study. Setting: University hospital medical center. Patients: Thirty-two consecutive patients surgically treated for various skin diseases and 26 consecutive patients with hypertrophic scars or keloids. Main Outcome Measures: Noninvasive bioengineering measurements of functional properties of the SC, such as transepidermal water loss (TEWL), high-frequency conductance, and SC turnover time. Results: The SC barrier function assessed by TEWL was found to be a better parameter for the functional evaluation of scars than the hydration state of the skin surface measured by high-frequency conductometry. In general, the SC on the scars of deeper wounds in the dermis took longer to normalize functionally than the SC on the scars of superficial wounds, especially on the thigh compared with the abdomen. Thus, elevated levels of TEWL observed on scars at the donor sites of split-thickness grafts normalized between 200 and 400 days in contrast to fewer than 50 days for those of subepidermal erosions. Both TEWL and high-frequency conductance remained high in hypertrophic scars and keloids, and the SC involved showed a faster turnover time than that of adjacent normal skin. Conclusions: Scars, a proliferative change of the dermis, can be objectively evaluated according to functional abnormalities of the SC, because the dermis has a close relationship with the epidermis and with the SC. The functional characteristics of the SC of fresh scars and those of hypertrophic scars and keloids resemble those of retinoid-treated skin, rather than those found in epidermal hyperproliferative conditions such as psoriasis and dermatitis.
引用
收藏
页码:1453 / 1458
页数:6
相关论文
共 25 条
[1]   MORPHOLOGY AND THICKNESS OF HUMAN STRATUM CORNEUM [J].
BLAIR, C .
BRITISH JOURNAL OF DERMATOLOGY, 1968, 80 (07) :430-&
[2]   THICKNESS OF STRATUM CORNEUMIN ACNE VULGARIS [J].
BLAIR, C .
BRITISH JOURNAL OF DERMATOLOGY, 1968, 80 (08) :516-&
[3]   ONCOSTATIN-M STIMULATES COLLAGEN AND GLYCOSAMINOGLYCAN PRODUCTION BY CULTURED NORMAL DERMAL FIBROBLASTS - INSENSITIVITY OF SCLERODERMAL AND KELOIDAL FIBROBLASTS [J].
DUNCAN, MR ;
HASAN, A ;
BERMAN, B .
JOURNAL OF INVESTIGATIVE DERMATOLOGY, 1995, 104 (01) :128-133
[4]  
Fusenig NE, 1994, KERATINOCYTE HDB, P71
[5]  
Glogau RG, 1994, J GERIATR DERMATOL, V2, P30
[6]  
Hara M., 1993, J GERIATR DERMATOL, V1, P111
[7]   INVITRO COMPARISON OF WATER-HOLDING CAPACITY OF THE SUPERFICIAL AND DEEPER LAYERS OF THE STRATUM-CORNEUM [J].
HASHIMOTOKUMASAKA, K ;
HORII, I ;
TAGAMI, H .
ARCHIVES OF DERMATOLOGICAL RESEARCH, 1991, 283 (05) :342-346
[8]   THERAPEUTIC SUCCESS OF EPIDERMAL GRAFTING IN GENERALIZED VITILIGO IS LIMITED BY THE KOEBNER PHENOMENON [J].
HATCHOME, N ;
KATO, T ;
TAGAMI, H .
JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY, 1990, 22 (01) :87-91
[9]   REGIONAL DIFFERENCES IN THICKNESS (CELL LAYERS) OF HUMAN STRATUM-CORNEUM - ULTRASTRUCTURAL ANALYSIS [J].
HOLBROOK, KA ;
ODLAND, GF .
JOURNAL OF INVESTIGATIVE DERMATOLOGY, 1974, 62 (04) :415-422
[10]  
INOUE K, 1990, J JPN SOC PLAST RECO, V10, P603