Tyrosine phosphorylation-dependence of caveolae-mediated endocytosis

被引：92

作者：

Sverdlov, Maria ^{[1
,2
]}

Shajahan, Ayesha N. ^{[1
,2
,3
]}

Minshall, Richard D. ^{[1
,2
]}

机构：

[1] Univ Illinois, Coll Med, Dept Pharmacol, Ctr Lung & Vasc Biol, Chicago, IL 60612 USA

[2] Univ Illinois, Coll Med, Dept Anesthesiol, Ctr Lung & Vasc Biol, Chicago, IL 60680 USA

[3] Georgetown Univ, Lombardi Comprehens Canc Ctr, Washington, DC USA

来源：

JOURNAL OF CELLULAR AND MOLECULAR MEDICINE | 2007年 / 11卷 / 06期

关键词：

caveolae; endocytosis; phosphorylation; Src; caveolin-1; actin cytoskeleton;

D O I：

10.1111/j.1582-4934.2007.00127.x

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Caveolae are flask-shaped plasma membrane invaginations that mediate endocytosis and transcytosis of plasma macromolecules, such as albumin, insulin and low-density lipoprotein (LDL), as well as certain viruses, bacteria and bacterial toxins. Caveolae-mediated transcytosis of macromolecules is critical for maintaining vascular homeostasis by regulating the oncotic pressure gradient and tissue delivery of drugs, vitamins, lipids and ions. Entrapment of cargo within caveolae induces activation of signalling cascades leading to caveolae fission and internalization. Activation of Src tyrosine kinase is an early and essential step that triggers detachment of loaded caveolae from the plasma membrane. In this review, we examine how Srcmediated phosphorylation regulates caveolae-mediated transport by orchestrating the localization and activity of essential proteins of the endocytic machinery to regulate caveolae formation and fission.

引用

页码：1239 / 1250

页数：12

共 100 条

[1] Src-dependent tyrosine phosphorylation regulates dynamin self-assembly and ligand-induced endocytosis of the epidermal growth factor receptor [J].