Levels of complexity in pathogen recognition by C-type lectins

被引：61
作者：
Cambi, A [1 ]
Figdor, CG [1 ]
机构：
[1] Radboud Univ Nijemgen Med Ctr, Nijmegen Ctr Mol Life Sci, Dept Tumor Immunol, Nijmegen, Netherlands
来源：
CURRENT OPINION IN IMMUNOLOGY | 2005年 / 17卷 / 04期
关键词：
D O I：
10.1016/j.coi.2005.05.011
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
In pathogen recognition by C-type lectins, several levels of complexity can be distinguished; these might modulate the immune response in different ways. Firstly, the pathogen-associated molecular pattern repertoire expressed at the microbial surface determines the interactions with specific receptors. Secondly, each immune cell type possesses a specific set of pathogen-recognition receptors. Thirdly, changes in the cell-surface distribution of C-type lectins regulate carbohydrate binding by modulating receptor affinity for different ligands. Crosstalk between these receptors results in a network of multimolecular complexes, adding a further level of complexity in pathogen recognition.
引用
收藏
页码：345 / 351
页数：7
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