Synthesis, Characterization, and Antimicrobial Evaluation of New Imidazo[2,1-b][1,3,4]thiadiazoles Bearing a Chroman Moiety

被引：4

作者：

Butani, S. C. ^{[1
]}

Vekariya, M. K. ^{[2
]}

Dholaria, P., V ^{[3
]}

Kapadiya, K. M. ^{[3
]}

Desai, N. D. ^{[1
]}

机构：

[1] Gujarat Univ, St Xaviers Coll, Dept Chem, Ahmadabad 380009, Gujarat, India

[2] Gujarat Univ, Sch Sci, Dept Chem, Ahmadabad 380009, Gujarat, India

[3] RK Univ, Biores & Characterizat Ctr, Sch Sci, Dept Chem, Rajkot 360020, Gujarat, India

来源：

RUSSIAN JOURNAL OF ORGANIC CHEMISTRY | 2022年 / 58卷 / 06期

关键词：

chroman; imidazo[2; 1-b][1; 3; 4]thiazoles; antibacterial activity; antifungal activity; DERIVATIVES; EFFICIENT; HYBRIDS; DESIGN;

D O I：

10.1134/S1070428022060185

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A series of 6-aryl-2-(6-fluoro-3,4-dihydro-2H-1-benzopyran-2-yl)imidazo[2,1-b][1,3,4]thiadiazoles were synthesized through a two-step procedure. The structure of the newly synthesized compounds was confirmed by IR, H-1 and C-13 NMR, and mass spectra and elemental analyses. All compounds were evaluated for their in vitro antibacterial and antifungal activity against two gram-positive and two gram-negative bacterial strains and one fungal strain. Fluoro-substituted compounds showed comparable biological activity against the tested microorganisms than the -Cl, -Br, and electron-donating groups concerning standard used.

引用

页码：878 / 883

页数：6

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