Cortical Spatio-temporal Dynamics Underlying Phonological Target Detection in Humans

被引:46
作者
Chang, Edward F. [1 ,2 ]
Edwards, Erik [2 ]
Nagarajan, Srikantan S.
Fogelson, Noa [2 ]
Dalal, Sarang S.
Canolty, Ryan T. [2 ]
Kirsch, Heidi E.
Barbaro, Nicholas M.
Knight, Robert T. [2 ]
机构
[1] Univ Calif San Francisco, Dept Neurol Surg, San Francisco, CA 94143 USA
[2] Univ Calif Berkeley, Berkeley, CA 94720 USA
关键词
HIGH GAMMA ACTIVITY; PREFRONTAL CORTEX; INTEGRATIVE THEORY; STIMULI; DISCRIMINATION; ELECTRODES; ATTENTION; RESPONSES; NEURONS;
D O I
10.1162/jocn.2010.21466
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Selective processing of task-relevant stimuli is critical for goal-directed behavior. We used electrocorticography to assess the spatio-temporal dynamics of cortical activation during a simple phonological target detection task, in which subjects press a button when a prespecified target syllable sound is heard. Simultaneous surface potential recordings during this task revealed a highly ordered temporal progression of high gamma (HG, 70200 Hz) activity across the lateral hemisphere in less than 1 sec. The sequence demonstrated concurrent regional sensory processing of speech syllables in the posterior superior temporal gyrus (STG) and speech motor cortex, and then transitioned to sequential task-dependent processing from prefrontal cortex (PFC), to the final motor response in the hand sensorimotor cortex. STG activation was modestly enhanced for target over nontarget sounds, supporting a selective gain mechanism in early sensory processing, whereas PFC was entirely selective to targets, supporting its role in guiding response behavior. These results reveal that target detection is not a single cognitive event, but rather a process of progressive target selectivity that involves large-scale rapid parallel and serial processing in sensory, cognitive, and motor structures to support goal-directed human behavior.
引用
收藏
页码:1437 / 1446
页数:10
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