Cell Therapy for Cardiovascular Disease: A Comparison of Methods of Delivery

被引：73

作者：

Dib, Nabil ^{[1
]}

Khawaja, Harris ^{[1
]}

Varner, Samantha ^{[1
]}

McCarthy, Megan ^{[1
]}

Campbell, Ann ^{[1
]}

机构：

[1] Mercy Gilbert & Chandler Reg Med Ctr, Gilbert, AZ 85297 USA

来源：

JOURNAL OF CARDIOVASCULAR TRANSLATIONAL RESEARCH | 2011年 / 4卷 / 02期

关键词：

Catheter; Intramyocardial delivery; Intravenous; Intracoronary; Coronary sinus; PRESSURE-REGULATED RETROINFUSION; MYOCARDIAL GENE-TRANSFER; MESENCHYMAL STEM-CELLS; INTRAMYOCARDIAL INJECTION; MYOBLAST TRANSPLANTATION; SKELETAL MYOBLASTS; CATHETER; FEASIBILITY; SAFETY; MODEL;

D O I：

10.1007/s12265-010-9253-z

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The field of myocardial regeneration utilizing novel cell-based therapies, gene transfer, and growth factors may prove to play an important role in the future management of ischemic heart disease and cardiomyopathy. Phases I and II clinical trials have been published for a variety of biologics utilizing four methods of delivery: systemic infusion, intracoronary infusion, transvenous coronary sinus, and intramyocardial. This review discusses the advantages and disadvantages of the delivery approaches above.

引用

页码：177 / 181

页数：5

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