3-acyl-2-(N-cyanoimino)oxazolidine derivative, a new asymmetric acylating agent for racemic secondary alkyl amines

被引：19
作者：
Maezaki, N
Furusawa, A
Uchida, S
Tanaka, T
机构：
[1] Osaka Univ, Grad Sch Pharmaceut Sci, Suita, Osaka 5650871, Japan
[2] Setsunan Univ, Fac Pharmaceut Sci, Hirakata, Osaka 5731041, Japan
来源：
TETRAHEDRON | 2001年 / 57卷 / 45期
关键词：
asymmetric reactions; resolution; acylation; amines;
D O I：
10.1016/S0040-4020(01)00933-4
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A 3-acyl-2-(N-cyanoimino)oxazolidine derivative was found to serve as an enantioselective acylating agent for sec-alkyl amines. These reagents differentiate the enantiomers of 1-phenylethylamine derivatives up to 85% ee, and the recovered chiral auxiliary is reusable. (C) 2001 Elsevier Science Ltd. All rights reserved.
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收藏
页码：9309 / 9315
页数：7
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