Limitations of Chromogranin A in clinical practice

被引：55

作者：

Marotta, Vincenzo ^{[1
]}

Nuzzo, Vincenzo ^{[2
]}

Ferrara, Teresa ^{[2
]}

Zuccoli, Alfonso ^{[2
]}

Masone, Milena ^{[3
]}

Nocerino, Lorenzo ^{[3
]}

Del Prete, Michela ^{[1
]}

Marciello, Francesca ^{[1
]}

Ramundo, Valeria ^{[1
]}

Lombardi, Gaetano ^{[1
]}

Vitale, Mario ^{[4
]}

Colao, Annamaria ^{[1
]}

Faggiano, Antongiulio ^{[1
,5
]}

机构：

[1] Univ Naples Federico II, Dept Mol & Clin Endocrinol & Oncol, I-80131 Naples, Italy

[2] Internal Med San Gennaro Hosp, Naples, Italy

[3] Nucl Med E DAosta Hosp, Naples, Italy

[4] Univ Salerno, Sch Med, I-84100 Salerno, Italy

[5] Natl Canc Inst Fdn G Pascale, Naples, Italy

来源：

BIOMARKERS | 2012年 / 17卷 / 02期

关键词：

Chromogranin A; neuroendocrine tumor; false positive marker; chronic atrophic gastritis; proton pump inhibitors; NEUROENDOCRINE TUMORS; ALPHA-SUBUNIT; GLYCOPROTEIN HORMONES; NEOPLASIA; MARKERS; CLASSIFICATION; HYPERTENSION; CARCINOMAS;

D O I：

10.3109/1354750X.2012.654511

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Context: Usefulness of circulating Chromogranin A (CgA) for the diagnosis of neuroendocrine tumors (NEN) is controversial. The aim of the present study was to assess the actual role of this marker as diagnostic tool. Methods: Serum blood samples were obtained from 42 subjects affected with NEN, 120 subjects affected with non-endocrine neoplasias (non-NEN) and 100 non-neoplastic subjects affected with benign nodular goitre (NNG). Determination of CgA was performed by means of immunoradiometric assay. Results: The CgA levels among NEN-patients were not significantly different from NNG and non-NEN subjects. The Receiver operating characteristic (ROC) curves analysis failed to identify a feasible cut-off value for the differential diagnosis between NEN and the other conditions. Conclusion: Serum CgA is not helpful for the first-line diagnosis of NEN.

引用

页码：186 / 191

页数：6

共 26 条

[1] Chromogranins as regulators of exocytosis
Borges, Ricardo
Diaz-Vera, Jesica
Dominguez, Natalia
Rosa Arnau, Maria
Machado, Jose D.
[J]. JOURNAL OF NEUROCHEMISTRY, 2010, 114 (02) : 335 - 343
[2] Chromogranin A: Is it a useful marker of neuroendocrine tumors?
Campana, Davide
Nori, Francesca
Piscitelli, Lidya
Morselli-Labate, Antonio Maria
Pezzilli, Raffaele
Corinaldesi, Roberto
Tomassetti, Paola
[J]. JOURNAL OF CLINICAL ONCOLOGY, 2007, 25 (15) : 1967 - 1973
[3] ENDOCRINE-CELLS IN COLORECTAL ADENOCARCINOMAS - INCIDENCE, HORMONE PROFILE AND PROGNOSTIC RELEVANCE
DEBRUINE, AP
WIGGERS, T
BEEK, C
VOLOVICS, A
VONMEYENFELDT, M
ARENDS, JW
BOSMAN, FT
[J]. INTERNATIONAL JOURNAL OF CANCER, 1993, 54 (05) : 765 - 771
[4] Edge S.B., 2010, AJCC cancer staging manual, V649
[5] Pulmonary and extrapulmonary poorly differentiated large cell neuroendocrine carcinomas - Diagnostic and prognostic features
Faggiano, Antongiulio
Sabourin, Jean-Cristophe
Ducreux, Michel
Lumbroso, Jean
Duvillard, Pierre
Leboulleux, Sophie
Dromain, Clarisse
Colao, Annamaria
Schlumberger, Martin
Baudin, Eric
[J]. CANCER, 2007, 110 (02) : 265 - 274
[6] The biological characterization of neuroendocrine tumors: The role of neuroendocrine markers
Ferolla, P.
Faggiano, A.
Mansueto, G.
Avenia, N.
Cantelmi, M. G.
Giovenali, P.
De Caro, M. L. Del Basso
Milone, F.
Scarpelli, G.
Masone, S.
Santeusanio, F.
Lombardi, G.
Angeletti, G.
Colao, A.
[J]. JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION, 2008, 31 (03) : 277 - 286
[7] Glinicki P, 2010, ENDOKRYNOL POL, V61, P384
[8] Goebel SU, 1999, CANCER-AM CANCER SOC, V85, P1470
[9] Plasma chromogranin A in patients with multiple endocrine neoplasia type 1
Granberg, D
Stridsberg, M
Seensalu, R
Eriksson, B
Lundqvist, G
Öberg, K
Skogseid, B
[J]. JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 1999, 84 (08) : 2712 - 2717
[10] Chromogranin A and the α-subunit of glycoprotein hormones in medullary thyroid carcinoma and phaeochromocytoma
Guignat, L
Bidart, JM
Nocera, M
Comoy, E
Schlumberger, M
Baudin, E
[J]. BRITISH JOURNAL OF CANCER, 2001, 84 (06) : 808 - 812

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