Limitations of Chromogranin A in clinical practice

被引：56

作者：

Marotta, Vincenzo ^{[1
]}

Nuzzo, Vincenzo ^{[2
]}

Ferrara, Teresa ^{[2
]}

Zuccoli, Alfonso ^{[2
]}

Masone, Milena ^{[3
]}

Nocerino, Lorenzo ^{[3
]}

Del Prete, Michela ^{[1
]}

Marciello, Francesca ^{[1
]}

Ramundo, Valeria ^{[1
]}

Lombardi, Gaetano ^{[1
]}

Vitale, Mario ^{[4
]}

Colao, Annamaria ^{[1
]}

Faggiano, Antongiulio ^{[1
,5
]}

机构：

[1] Univ Naples Federico II, Dept Mol & Clin Endocrinol & Oncol, I-80131 Naples, Italy

[2] Internal Med San Gennaro Hosp, Naples, Italy

[3] Nucl Med E DAosta Hosp, Naples, Italy

[4] Univ Salerno, Sch Med, I-84100 Salerno, Italy

[5] Natl Canc Inst Fdn G Pascale, Naples, Italy

来源：

BIOMARKERS | 2012年 / 17卷 / 02期

关键词：

Chromogranin A; neuroendocrine tumor; false positive marker; chronic atrophic gastritis; proton pump inhibitors; NEUROENDOCRINE TUMORS; ALPHA-SUBUNIT; GLYCOPROTEIN HORMONES; NEOPLASIA; MARKERS; CLASSIFICATION; HYPERTENSION; CARCINOMAS;

D O I：

10.3109/1354750X.2012.654511

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Context: Usefulness of circulating Chromogranin A (CgA) for the diagnosis of neuroendocrine tumors (NEN) is controversial. The aim of the present study was to assess the actual role of this marker as diagnostic tool. Methods: Serum blood samples were obtained from 42 subjects affected with NEN, 120 subjects affected with non-endocrine neoplasias (non-NEN) and 100 non-neoplastic subjects affected with benign nodular goitre (NNG). Determination of CgA was performed by means of immunoradiometric assay. Results: The CgA levels among NEN-patients were not significantly different from NNG and non-NEN subjects. The Receiver operating characteristic (ROC) curves analysis failed to identify a feasible cut-off value for the differential diagnosis between NEN and the other conditions. Conclusion: Serum CgA is not helpful for the first-line diagnosis of NEN.

引用

页码：186 / 191

页数：6

共 26 条

[1] Chromogranins as regulators of exocytosis [J].