MICRORNAS IN HEART DEVELOPMENT

被引：63

作者：

Espinoza-Lewis, Ramon A. ^{[1
]}

Wang, Da-Zhi ^{[1
]}

机构：

[1] Harvard Univ, Sch Med, Cardiovasc Res Div, Dept Cardiol,Childrens Hosp Boston, Boston, MA 02115 USA

来源：

HEART DEVELOPMENT | 2012年 / 100卷

关键词：

HETEROCHRONIC GENE LIN-14; EMBRYONIC STEM-CELLS; RNA-INTERFERENCE; C-ELEGANS; NUCLEAR EXPORT; TRANSCRIPTION FACTOR; POSTTRANSCRIPTIONAL REGULATION; CARDIAC-HYPERTROPHY; REGULATE EXPRESSION; ECTOPIC EXPRESSION;

D O I：

10.1016/B978-0-12-387786-4.00009-9

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

MicroRNAs (miRNAs) are a class of small noncoding RNAs of similar to 22 nt in length which are involved in the regulation of gene expression at the posttranscriptional level by degrading their target mRNAs and/or inhibiting their translation. Expressed ubiquitously or in a tissue-specific manner, miRNAs are involved in the regulation of many biological processes such as cell proliferation, differentiation, apoptosis, and the maintenance of normal cellular physiology. Many miRNAs are expressed in embryonic, postnatal, and adult hearts. Aberrant expression or genetic deletion of miRNAs is associated with abnormal cardiac cell differentiation, disruption of heart development, and cardiac dysfunction. This chapter will summarize the history, biogenesis, and processing of miRNAs as well as their function in heart development, remodeling, and disease.

引用

页码：279 / 317

页数：39

共 178 条

[1] The Role of MicroRNA-133 in Cardiac Hypertrophy Uncovered [J].