Regulation of Energy Homeostasis and as a Potential Target for Alleviating Metabolic Diseases

被引:44
作者
Peppler, Willem T. [1 ]
Townsend, Logan K. [1 ]
Knuth, Carly M. [1 ]
Foster, Michelle T. [2 ]
Wright, David C. [1 ]
机构
[1] Univ Guelph, Dept Human Hlth & Nutr Sci, 50 Stone Rd E, Guelph, ON N1G 2W1, Canada
[2] Colorado State Univ, Dept Food Sci & Human Nutr, Ft Collins, CO 80523 USA
来源
AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM | 2018年 / 314卷 / 01期
基金
加拿大自然科学与工程研究理事会;
关键词
adipose tissue; exercise; glucose; metabolism; physical activity; SUBCUTANEOUS ADIPOSE-TISSUE; PROTEIN-KINASE B; HIGH-FAT DIET; MITOCHONDRIAL-ENZYMES; EXHAUSTIVE EXERCISE; BROWN; WHITE; GLUCOSE; BEIGE; THERMOGENESIS;
D O I
10.1152/ajpendo.00226.2017
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Exercise training has robust effects on subcutaneous inguinal white adipose tissue (iWAT), characterized by a shift to a brown adipose tissue (BAT)-like phenotype. Consistent with this, transplantation of exercise-trained iWAT into sedentary rodents activates thermogenesis and improves glucose homeostasis, suggesting that iWAT metabolism may contribute to the beneficial effects of exercise. However, it is yet to be determined if adaptations in iWAT are necessary for the beneficial systemic effects of exercise. To test this, male C57BL/6 mice were provided access to voluntary wheel running (VWR) or remained as a cage control (SED) for 11 nights after iWAT removal via lipectomy (LIPX) or SHAM surgery. We found that SHAM and LIPX mice with access to VWR ran similar distances and had comparable reductions in body mass, increased food intake, and increased respiratory exchange ratio (RER). Further, VWR improved indexes of glucose homeostasis and insulin tolerance in both SHAM and LIPX mice. The lack of effect of LIPX in the response to VWR was not explained by compensatory increases in markers of mitochondrial biogenesis and thermogenesis in skeletal muscle, epididymal white adipose tissue, or interscapular brown adipose tissue. Together, these data demonstrate that mice with and without iWAT have comparable adaptations to VWR, suggesting that iWAT may be dispensable for the metabolic health benefits of exercise.
引用
收藏
页码:E66 / E77
页数:12
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