SMARCAD1 Promotes Pancreatic Cancer Cell Growth and Metastasis through Wnt/β-catenin-Mediated EMT

被引：33

作者：

Liu, Furao ^{[1
,2
]}

Xia, Zebin ^{[3
]}

Zhang, Meichao ^{[1
,2
]}

Ding, Jianwei ^{[1
,2
]}

Feng, Yang ^{[1
,2
]}

Wu, Jianwei ^{[1
,2
]}

Dong, Yun ^{[1
,2
]}

Gao, Wei ^{[1
,2
]}

Han, Zengwei ^{[1
,2
]}

Liu, Yuanhua ^{[4
]}

Yao, Yuan ^{[1
,2
]}

Li, Dong ^{[1
,2
]}

机构：

[1] Shanghai Jiao Tong Univ, Hainan West Cent Hosp, Dept Radiat Oncol, Hainan Branch,Sch Med,Shanghai Peoples Hosp 9, Shanghai, Hainan, Peoples R China

[2] Shanghai Jiao Tong Univ, Shanghai Peoples Hosp 9, Dept Radiat Oncol, Sch Med, Shanghai, Peoples R China

[3] DaHua Hosp, Dept Gen Surg, Shanghai, Peoples R China

[4] Nanjing Med Univ, Canc Inst Jiangsu Prov, Dept Chemotherapy, Affiliated Canc Hosp, Nanjing, Jiangsu, Peoples R China

来源：

INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES | 2019年 / 15卷 / 03期

基金：

中国国家自然科学基金;

关键词：

SMARCAD1; metastasis; EMT; Wnt/beta-catenin; EPITHELIAL-MESENCHYMAL TRANSITION; SWI/SNF COMPLEX; CHROMATIN; DNA; FAMILY; WNT; CHEMORESISTANCE; MODULATION; EXPRESSION; CARCINOMA;

D O I：

10.7150/ijbs.29562

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Pancreatic cancer (PC) is one of the most lethal diseases, characterized by early metastasis and high mortality. Subunits of the SWI/SNF complex have been identified in many studies as the regulators of tumor progression, but the role of SMARCAD1, one member of the SWI/SNF family, in pancreatic cancer has not been elucidated. Based on analysis of GEO database and immunohistochemical detection of patient-derived pancreatic cancer tissues, we found that SMARCAD1 is more highly expressed in pancreatic cancer tissues and that its expression level negatively correlates with patients' survival time. With further investigation, it shows that SMARCAD1 promotes the proliferation, migration, invasion of pancreatic cancer cells. Mechanistically, we first demonstrate that SMARCAD1 induces EMT via activating Wnt/beta-catenin signaling pathway in pancreatic cancer. Our results provide the role and potential mechanism of SMARCAD1 in pancreatic cancer, which may prove useful marker for diagnostic or therapeutic applications of PC disease.

引用

页码：636 / 646

页数：11

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