共 27 条
Lipoproteins of Listeria monocytogenes are critical for virulence and TLR2-mediated immune activation
被引:76
作者:

Machata, Silke
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Univ Giessen, Inst Med Mikrobiol, D-35392 Giessen, Germany Univ Giessen, Inst Med Mikrobiol, D-35392 Giessen, Germany

Tchatalbachev, Svetlin
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Univ Giessen, Inst Med Mikrobiol, D-35392 Giessen, Germany Univ Giessen, Inst Med Mikrobiol, D-35392 Giessen, Germany

Mohamed, Walid
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Univ Giessen, Inst Med Mikrobiol, D-35392 Giessen, Germany Univ Giessen, Inst Med Mikrobiol, D-35392 Giessen, Germany

Jaensch, Lothar
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机构:
Helmholtz Ctr Infect Res, Braunschweig, Germany Univ Giessen, Inst Med Mikrobiol, D-35392 Giessen, Germany

Hain, Torsten
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Univ Giessen, Inst Med Mikrobiol, D-35392 Giessen, Germany Univ Giessen, Inst Med Mikrobiol, D-35392 Giessen, Germany

Chakraborty, Trinad
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Univ Giessen, Inst Med Mikrobiol, D-35392 Giessen, Germany Univ Giessen, Inst Med Mikrobiol, D-35392 Giessen, Germany
机构:
[1] Univ Giessen, Inst Med Mikrobiol, D-35392 Giessen, Germany
[2] Helmholtz Ctr Infect Res, Braunschweig, Germany
关键词:
D O I:
10.4049/jimmunol.181.3.2028
中图分类号:
R392 [医学免疫学];
Q939.91 [免疫学];
学科分类号:
100102 ;
摘要:
Numerous cell surface components of Listeria influence and regulate innate immune recognition and virulence. Here, we demonstrate that lipidation of prelipoproteins in Listeria monocytogenes is required to promote NF-kappa B activation via TLR2. In HeLa cells transiently expressing TLR2, L. monocytogenes and Listeria innocua mutants lacking the prolipoprotein diacylglyceryl transferase (lgt) gene are unable to induce TLR2-dependent activation of NF-kappa B, a property intrinsic to their isogenic parental strains. TLR2-dependent immune recognition is directed to secreted, soluble lipoproteins as evidenced by the sensitivity of the response to lipoprotein lipase. Studies of bone marrow-derived macrophages of C57BL/6 wild-type and TLR2-deficient mice infected with wild-type and lgt mutant strains indicate that the absence of host TLR2 receptor signaling has consequences similar to those of the absence of the bacterial TLR2 ligand, i.e., a delay in cellular immune responses directed toward the bacterium. Infection studies with the wild-type and TLR2(-/-) mice indicated attenuation of the lgt deletion mutant in both mouse strains, implying multiple roles of lipoproteins during infection. Further characterization of the Delta lgt mutant indicated that it is impaired for both invasion and intracellular survival and exhibits increased susceptibility to cationic peptides. Our studies identify lipoproteins as the immunologically active ligand of TLR2 and assign a critical role for this receptor in the recognition of these bacteria during infection, but they also reveal the overall importance of the lipoproteins for the pathogenicity of Listeria.
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页码:2028 / 2035
页数:8
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