Long non-coding RNAs and prostate cancer

被引：116
作者：
Misawa, Aya [1 ]
Takayama, Ken-ichi [1 ,2 ]
Inoue, Satoshi [1 ,2 ,3 ]
机构：
[1] Univ Tokyo, Grad Sch Med, Dept Antiaging Med, Tokyo, Japan
[2] Tokyo Metropolitan Inst Gerontol, Dept Funct Biogerontol, Tokyo, Japan
[3] Saitama Med Univ, Res Ctr Genom Med, Div Gene Regulat & Signal Transduct, Saitama, Japan
来源：
CANCER SCIENCE | 2017年 / 108卷 / 11期
关键词：
Androgen; androgen receptor; castration resistant prostate cancer; long non-coding RNA; prostate cancer; POTENTIAL THERAPEUTIC TARGET; ADENOCARCINOMA TRANSCRIPT 1; UP-REGULATION; RADICAL PROSTATECTOMY; PROGNOSTIC MARKER; IMPRINTED GENES; GROWTH ARREST; CELL-GROWTH; HOTAIR; METASTASIS;
D O I：
10.1111/cas.13352
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Long non-coding RNAs (lncRNAs) are RNA transcripts larger than 200 nucleotides that do not code for proteins the aberrant expression of which has been documented in various types of cancer, including prostate cancer. Lack of appropriate sensitive and specific biomarkers for prostate cancer has led to overdiagnosis and overtreatment, making lncRNAs promising novel biomarkers as well as therapeutic targets for the disease. The present review attempts to summarize the current knowledge of lncRNA expression patterns and mechanisms in prostate cancer, which contribute to carcinogenesis. In particular, we focused on lncRNAs regulated by androgen receptor and expressed in castration-resistant prostate cancer.
引用
收藏
页码：2107 / 2114
页数：8
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