Utilization of F1 information in estimating QTL effects in F2 crosses between outbred lines

被引：2

作者：

Daley, J. W. ^{[1
]}

Shepherd, R. K. ^{[1
]}

机构：

[1] Univ Cent Queensland, Sch Comp Sci, Rockhampton, Qld 4701, Australia

来源：

JOURNAL OF ANIMAL BREEDING AND GENETICS | 2008年 / 125卷 / 01期

关键词：

F-2; design; outbred lines; QTL; REML; segment mapping;

D O I：

10.1111/j.1439-0388.2007.00699.x

中图分类号：

S8 [畜牧、动物医学、狩猎、蚕、蜂];

学科分类号：

0905 ;

摘要：

Quantitative trait loci (QTL) analysis in designed experiments is investigated using a mixed model framework through the modification of segment mapping techniques. Allele effects are modelled in the F, generation allowing the estimation of additive substitution effects while accounting for QTL segregation within lines and differences in mean QTL effects between lines. The resulting approach is called F, segment mapping. Simulation is used to illustrate the method and its properties. F-1 segment mapping has advantages over F-2 segment mapping in the derivation of exact additive genetic covariances and in the computation time for variance component estimation.

引用

页码：35 / 44

页数：10

共 17 条

[1] Likelihood ratio tests in linear mixed models with one variance component [J].

Crainiceanu, CM ;

Ruppert, D .

JOURNAL OF THE ROYAL STATISTICAL SOCIETY SERIES B-STATISTICAL METHODOLOGY, 2004, 66 :165-185

[2] MARKER ASSISTED SELECTION USING BEST LINEAR UNBIASED PREDICTION [J].

FERNANDO, RL ;

GROSSMAN, M .

GENETICS SELECTION EVOLUTION, 1989, 21 (04) :467-477

[3]

FULKER DW, 1994, AM J HUM GENET, V54, P1092

[4]

Gilmour A.R., 2006, ASREML USER GUIDE RE

[5] A MIXED MODEL FOR ANALYSES OF DATA ON MULTIPLE GENETIC-MARKERS [J].

GODDARD, ME .

THEORETICAL AND APPLIED GENETICS, 1992, 83 (6-7) :878-886

[6]

Haldane JBS, 1919, J GENET, V8, P299

[7] A SIMPLE REGRESSION METHOD FOR MAPPING QUANTITATIVE TRAIT LOCI IN LINE CROSSES USING FLANKING MARKERS [J].

HALEY, CS ;

KNOTT, SA .

HEREDITY, 1992, 69 :315-324

[8]

HALEY CS, 1994, GENETICS, V136, P1195

[9]

JANSEN RC, 1993, GENETICS, V135, P205

[10]

Kao CH, 1999, GENETICS, V152, P1203

← 1 2 →