Convenient synthesis of a central 2,3,6-trisubstituted pyridine skeleton of a macrobicyclic antibiotic, cyclothiazomycin

被引:15
作者
Okabe, A [1 ]
Ito, A [1 ]
Okumura, K [1 ]
Shin, C [1 ]
机构
[1] Kanagawa Univ, Fac Technol, Organ Chem Lab, Kanagawa Ku, Yokohama, Kanagawa 2218686, Japan
关键词
D O I
10.1246/cl.2001.380
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
The first convenient synthesis of the main central 2,3,6-trisubstituted pyridine skeleton [protected Fragment A-B] of a macrobicyclic antibiotic, cyclothiazomycin, was achieved.
引用
收藏
页码:380 / 381
页数:2
相关论文
共 5 条
[1]   CYCLOTHIAZOMYCIN, A NOVEL POLYTHIAZOLE-CONTAINING PEPTIDE WITH RENIN INHIBITORY ACTIVITY - TAXONOMY, FERMENTATION, ISOLATION AND PHYSICOCHEMICAL CHARACTERIZATION [J].
AOKI, M ;
OHTSUKA, T ;
YAMADA, M ;
OHBA, Y ;
YOSHIZAKI, H ;
YASUNO, H ;
SANO, T ;
WATANABE, J ;
YOKOSE, K ;
SETO, H .
JOURNAL OF ANTIBIOTICS, 1991, 44 (06) :582-588
[2]   NEW METHODS AND REAGENTS IN ORGANIC-SYNTHESIS .67. A GENERAL-SYNTHESIS OF DERIVATIVES OF OPTICALLY PURE 2-(1-AMINOALKYL)THIAZOLE-4-CARBOXYLIC ACIDS [J].
HAMADA, Y ;
SHIBATA, M ;
SUGIURA, T ;
KATO, S ;
SHIOIRI, T .
JOURNAL OF ORGANIC CHEMISTRY, 1987, 52 (07) :1252-1255
[3]   AN EFFICIENT SYNTHESIS OF 6-FORMYL-1,2-DIHYDRO-2-OXO-3-PYRIDINECARBOXYLIC ACID AND SOME CARBONYL DERIVATIVES OF IT AND ITS 6-ACETYL HOMOLOG [J].
SANCHEZ, JP ;
MICH, TF ;
HUANG, GG .
JOURNAL OF HETEROCYCLIC CHEMISTRY, 1994, 31 (02) :297-303
[4]   PRACTICAL SYNTHESIS OF OXAZOLES INCORPORATED IN ALPHA-DEHYDROAMINO ACID AND DEHYDROPEPTIDE STRUCTURES [J].
SHIN, C ;
NAKAMURA, Y ;
OKUMURA, K .
CHEMISTRY LETTERS, 1993, (08) :1405-1408
[5]   A CONVENIENT SYNTHESIS OF METHYL 2-[2-(1-AMINO)ETHENYL-BITHIAZOLYL] THIAZOLINE-4-CARBOXYLATE, AN IMPORTANT SKELETON OF CYCLOTHIAZOMYCIN [J].
SHIN, CG ;
ITO, A ;
OKUMURA, K ;
NAKAMURA, Y .
CHEMISTRY LETTERS, 1995, (01) :45-46