Current perspectives on psychedelic therapy: use of serotonergic hallucinogens in clinical interventions

被引:117
作者
Garcia-Romeu, Albert [1 ]
Richards, William A. [1 ]
机构
[1] Johns Hopkins Univ, Sch Med, Dept Psychiat & Behav Sci, Baltimore, MD 21205 USA
关键词
Psychedelic therapy; hallucinogens; psilocybin; LSD; LYSERGIC-ACID DIETHYLAMIDE; POSTTRAUMATIC-STRESS-DISORDER; MYSTICAL-TYPE EXPERIENCES; MONOAMINE-OXIDASE INHIBITORS; LIFE-THREATENING CANCER; TERM-FOLLOW-UP; ASSISTED PSYCHOTHERAPY; DOUBLE-BLIND; CHALLENGING EXPERIENCES; FUNCTIONAL CONNECTIVITY;
D O I
10.1080/09540261.2018.1486289
中图分类号
R749 [精神病学];
学科分类号
100205 ;
摘要
Humans have used serotonergic hallucinogens (i.e. psychedelics) for spiritual, ceremonial, and recreational purposes for thousands of years, but their administration as part of a structured therapeutic intervention is still a relatively novel practice within Western medical and psychological frameworks. In the mid-20th century, considerable advances were made in developing therapeutic approaches integrating administration of low (psycholytic) and high (psychedelic) doses of serotonergic hallucinogens for treatment of a variety of conditions, often incorporating psychoanalytic concepts prevalent at that time. This work contributed seminal insights regarding how these substances may be employed with efficacy and safety in targeted therapeutic interventions, including the importance of optimizing set (frame of mind) and setting (therapeutic environment). More recently, clinical and pharmacological research has revisited the effects and therapeutic potential of psychedelics utilizing a variety of approaches. The current article provides an overview of past and present models of psychedelic therapy, and discusses important considerations for future interventions incorporating the use of psychedelics in research and clinical practice.
引用
收藏
页码:291 / 316
页数:26
相关论文
共 278 条
[61]  
DOBLIN R, 1991, J TRANSPERSONAL PSY, V23, P1
[62]   Pharmacokinetics and Concentration-Effect Relationship of Oral LSD in Humans [J].
Dolder, Patrick C. ;
Schmid, Yasmin ;
Haschke, Manuel ;
Rentsch, Katharina M. ;
Liechti, Matthias E. .
INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY, 2016, 19 (01) :1-7
[63]   Classical hallucinogens and neuroimaging: A systematic review of human studies Hallucinogens and neuroimaging [J].
dos Santos, Rafael G. ;
Osorio, Flavia L. ;
Crippa, Jose Alexandre S. ;
Hallak, Jaime E. C. .
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS, 2016, 71 :715-728
[64]   Flashback: Psychiatric experimentation with LSD in historical perspective [J].
Dyck, E .
CANADIAN JOURNAL OF PSYCHIATRY-REVUE CANADIENNE DE PSYCHIATRIE, 2005, 50 (07) :381-388
[65]  
Ellis H.L., 1897, The Lancet, V149, P1540, DOI DOI 10.1016/S0140-6736(01)95215-8
[66]   The conceptualization and measurement of therapeutic alliance: An empirical review [J].
Elvins, Rachel ;
Green, Jonathan .
CLINICAL PSYCHOLOGY REVIEW, 2008, 28 (07) :1167-1187
[67]   Lessons to be learned from early psychedelic therapy in Denmark [J].
Erritzoe, David ;
Richards, William A. .
NORDIC JOURNAL OF PSYCHIATRY, 2017, 71 (07) :487-488
[68]  
Fadiman J., 2011, The psychedelic explorer's guide: safe, therapeutic, and sacred journeys
[69]  
Ferrer JorgeN., 2002, REVISIONING TRANSPER
[70]   Jimsonweed (Datura stramonium) exposures in Texas, 1998-2004 [J].
Forrester, Mathias B. .
JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH-PART A-CURRENT ISSUES, 2006, 69 (19) :1757-1762