Glycans in cancer and inflammation. Potential for therapeutics and diagnostics

被引：1380

作者：

Dube, DH

Bertozzi, CR ^{[1
]}

机构：

[1] Univ Calif Berkeley, Lawrence Berkeley Lab, Div Sci Mat, Dept Chem, Berkeley, CA 94720 USA

[2] Univ Calif Berkeley, Lawrence Berkeley Lab, Div Sci Mat, Dept Mol & Cell Biol, Berkeley, CA 94720 USA

[3] Univ Calif Berkeley, Lawrence Berkeley Lab, Div Sci Mat, Howard Hughes Med Inst, Berkeley, CA 94720 USA

来源：

NATURE REVIEWS DRUG DISCOVERY | 2005年 / 4卷 / 06期

关键词：

D O I：

10.1038/nrd1751

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Changes in glycosylation are often a hallmark of disease states. For example, cancer cells frequently display glycans at different levels or with fundamentally different structures than those observed on normal cells. This phenomenon was first described in the early 1970s, but the molecular details underlying such transformations were poorly understood. In the past decade advances in genomics, proteomics and mass spectrometry have enabled the association of specific glycan structures with disease states. In some cases, the functional significance of disease-associated changes in glycosylation has been revealed. This review highlights changes in glycosylation associated with cancer and chronic inflammation and new therapeutic and diagnostic strategies that are based on the underlying glycobiology.

引用

页码：477 / 488

页数：12

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[71] COMPARATIVE STUDIES ON CARBOHYDRATE-CONTAINING MEMBRANE COMPONENTS OF NORMAL AND VIRUS-TRANSFORMED MOUSE FIBROBLASTS .2. SEPARATION OF GLYCOPROTEINS AND GLYCOPEPTIDES BY SEPHADEX CHROMATOGRAPHY [J].