Clinical Impact of 68Ga-PSMA PET/CT in a Patient With Biochemical Recurrence of Prostate Cancer

被引：6

作者：

Queiroz, Marcelo A. ^{[1
]}

Viana, Publio ^{[1
]}

Santos, Allan ^{[2
]}

Bastos, Diogo ^{[3
]}

Etchebehere, Elba ^{[2
]}

Cerri, Giovanni ^{[1
]}

机构：

[1] Sirio Libanes Hosp, Div Radiol, Sao Paulo, Brazil

[2] Sirio Libanes Hosp, Div Nucl Med, Sao Paulo, Brazil

[3] Sirio Libanes Hosp, Med Oncol Ctr, Sao Paulo, Brazil

来源：

CLINICAL NUCLEAR MEDICINE | 2016年 / 41卷 / 09期

关键词：

PET/CT; 68Ga-PSMA; prostate cancer; radical prostatectomy; biochemical recurrence; metastasis; RADICAL PROSTATECTOMY; LIGAND;

D O I：

10.1097/RLU.0000000000001264

中图分类号：

R8 [特种医学]; R445 [影像诊断学];

学科分类号：

1002 ; 100207 ; 1009 ;

摘要：

A 64-year-old man with history of prostate adenocarcinoma underwent radical prostatectomy in 2003. He remained with undetectable prostate-specific antigen (PSA) levels until 2014, when he then presented rising serum PSA levels and performed a Tc-99m-MDP bone scan that was negative for metastases. In August 2015, his PSA was 4.89 ng/dL, and restaging images with pelvic MR and F-18-FDG PET/CT were both negative. Therefore, the patient underwent a Ga-68-PSMA PET/CT that showed marked tracer uptake in a single mediastinal lymph node. Histopathology demonstrated metastatic adenocarcinoma secondary to prostate cancer, altering patient management to hormone therapy instead of pelvic radiotherapy.

引用

页码：E417 / E419

页数：3

共 9 条

[1] PET imaging with a [68Ga]gallium-labelled PSMA ligand for the diagnosis of prostate cancer: biodistribution in humans and first evaluation of tumour lesions [J].

Afshar-Oromieh, A. ;

Malcher, A. ;

Eder, M. ;

Eisenhut, M. ;

Linhart, H. G. ;

Hadaschik, B. A. ;

Holland-Letz, T. ;

Giesel, F. L. ;

Kratochwil, C. ;

Haufe, S. ;

Haberkorn, U. ;

Zechmann, C. M. .

EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING, 2013, 40 (04) :486-495

[2] Comparison of PET imaging with a 68Ga-labelled PSMA ligand and 18F-choline-based PET/CT for the diagnosis of recurrent prostate cancer [J].

Afshar-Oromieh, Ali ;

Zechmann, Christian M. ;

Malcher, Anna ;

Eder, Matthias ;

Eisenhut, Michael ;

Linhart, Heinz G. ;

Holland-Letz, Tim ;

Hadaschik, Boris A. ;

Giesel, Frederik L. ;

Debus, Juergen ;

Haberkorn, Uwe .

EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING, 2014, 41 (01) :11-20

[3] 68Ga-PSMA PET/CT for restaging recurrent prostate cancer: which factors are associated with PET/CT detection rate? [J].

Ceci, Francesco ;

Uprimny, Christian ;

Nilica, Bernhard ;

Geraldo, Llanos ;

Kendler, Dorota ;

Kroiss, Alexander ;

Bektic, Jasmin ;

Horninger, Wolfgang ;

Lukas, Peter ;

Decristoforo, Clemens ;

Castellucci, Paolo ;

Fanti, Stefano ;

Virgolini, Irene J. .

EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING, 2015, 42 (08) :1284-1294

[4] Prostate-Specific Membrane Antigen-Based Imaging in Prostate Cancer: Impact on Clinical Decision Making Process [J].

Demirkol, Mehmet Onur ;

Acar, Omer ;

Ucar, Burcu ;

Ramazanoglu, Sultan Rana ;

Saglican, Yesim ;

Esen, Tarik .

PROSTATE, 2015, 75 (07) :748-757

[5] Evaluation of Hybrid 68Ga-PSMA Ligand PET/CT in 248 Patients with Biochemical Recurrence After Radical Prostatectomy [J].

Eiber, Matthias ;

Maurer, Tobias ;

Souvatzoglou, Michael ;

Beer, Ambros J. ;

Ruffani, Alexander ;

Haller, Bernhard ;

Graner, Frank-Philipp ;

Kuebler, Hubert ;

Haberhorn, Uwe ;

Eisenhut, Michael ;

Wester, Hans-Juergen ;

Gschwend, Juergen E. ;

Schwaiger, Markus .

JOURNAL OF NUCLEAR MEDICINE, 2015, 56 (05) :668-674

[6] Prospective comparison of computed tomography, diffusion-weighted magnetic resonance imaging and [11C]choline positron emission tomography/computed tomography for preoperative lymph node staging in prostate cancer patients [J].

Heck, Matthias M. ;

Souvatzoglou, Michael ;

Retz, Margitta ;

Nawroth, Roman ;

Kuebler, Hubert ;

Maurer, Tobias ;

Thalgott, Mark ;

Gramer, Bettina M. ;

Weirich, Gregor ;

Rondak, Ina-Christine ;

Rummeny, Ernst J. ;

Schwaiger, Markus ;

Gschwend, Jurgen E. ;

Krause, Bernd ;

Eiber, Matthias .

EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING, 2014, 41 (04) :694-701

[7] Molecular imaging of prostate cancer: translating molecular biology approaches into the clinical realm [J].

Vargas, Hebert Alberto ;

Grimm, Jan ;

Donati, Olivio F. ;

Sala, Evis ;

Hricak, Hedvig .

EUROPEAN RADIOLOGY, 2015, 25 (05) :1294-1302

[8] Extent of disease in recurrent prostate cancer determined by [68Ga]PSMA-HBED-CC PET/CT in relation to PSA levels, PSA doubling time and Gleason score [J].

Verburg, Frederik A. ;

Pfister, David ;

Heidenreich, Axel ;

Vogg, Andreas ;

Drude, Natascha I. ;

Voo, Stefan ;

Mottaghy, Felix M. ;

Behrendt, Florian F. .

EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING, 2016, 43 (03) :397-403

[9] The long-term clinical impact of biochemical recurrence of prostate cancer 5 or more years after radical prostatectomy [J].

Ward, JF ;

Blute, ML ;

Slezak, J ;

Bergstralh, EJ ;

Zincke, H .

JOURNAL OF UROLOGY, 2003, 170 (05) :1872-1876

← 1 →