Isolated mouse inner cell mass is unable to reconstruct trophectoderm

被引：13
|
作者：
Szczepanska, Katarzyna [1 ]
Stanczuk, Lukasz [1 ]
Maleszewski, Marek [1 ]
机构：
[1] Univ Warsaw, Dept Embryol, Inst Zool, PL-02096 Warsaw, Poland
来源：
DIFFERENTIATION | 2011年 / 82卷 / 01期
关键词：
Mouse; Embryo; Blastocyst; TE; ICM; Cdx2; EARLY MAMMALIAN DEVELOPMENT; DETERMINATIVE STATE; EARLY EMBRYO; DIFFERENTIATION; BLASTOCYST; EXPRESSION; CDX2; FATE; IMMUNOSURGERY; TOTIPOTENCY;
D O I：
10.1016/j.diff.2011.04.001
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
The ability of ICM to differentiate into TE is still a controversial issue. Many of authors have showed the reconstruction of TE from isolated ICMs. We showed that immunosurgical method is not 100% efficient and that the original TE cells very often remain on the surface of isolated ICMs. We also found that isolated ICM cells cultured in vitro do not express Cdx2, and that the TE is reconstituted from TE cells which have survived immunosurgery. This indicates that very soon after the formation of TE in the blastocyst, the cells of ICM lose the potency to differentiate into trophectoderm. (C) 2011 International Society of Differentiation. Published by Elsevier Ltd. All rights reserved.
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页码：1 / 8
页数：8
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