The MRP family of drug efflux pumps

被引：497
作者：
Kruh, GD [1 ]
Belinsky, MG [1 ]
机构：
[1] Fox Chase Canc Ctr, Div Med Sci, Philadelphia, PA 19111 USA
来源：
ONCOGENE | 2003年 / 22卷 / 47期
关键词：
ABC transporter; efflux; resistance;
D O I：
10.1038/sj.onc.1206953
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The MRP family is comprised of nine related ABC transporters that are able to transport structurally diverse lipophilic anions and function as drug efflux pumps. Investigations of this family have provided insights not only into cellular resistance mechanisms associated with natural product chemotherapeutic agents, antifolates and nucleotide analogs, but also into factors that influence drug distribution in the body, membrane systems that are involved in the extrusion of reduced folates, cysteinyl leukotrienes and bile acids, and the molecular basis of two hereditary conditions in humans. The review will describe the biochemical properties, drug resistance activities and potential in vivo functions of these unusual pumps.
引用
收藏
页码：7537 / 7552
页数：16
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