Circulating fetal and total cell-free DNA, and sHLA-G in black South African women with gestational hypertension and pre-eclampsia

被引：24
作者：
Eche, Simeon [1 ]
Mackraj, Irene [1 ]
Moodley, Jagidesa [2 ,3 ]
机构：
[1] Univ KwaZulu Natal, Discipline Human Physiol, Durban, South Africa
[2] Univ KwaZulu Natal, Nelson R Mandela Sch Med, Discipline Obstet & Gynecol, Durban, South Africa
[3] Univ KwaZulu Natal, Nelson R Mandela Sch Med, Womens Hlth & HIV Res Grp, Durban, South Africa
来源：
HYPERTENSION IN PREGNANCY | 2017年 / 36卷 / 04期
基金：
新加坡国家研究基金会;
关键词：
Fetal cell-free DNA; total cell-free DNA; soluble human leucocyte antigen; pre-eclampsia; gestational hypertension; SOLUBLE HLA-G; MATERNAL PLASMA; ANGIOGENIC FACTORS; G PROTEIN; DISORDERS; PREGNANCY; MANAGEMENT; DIAGNOSIS; PLACENTA; RASSF1A;
D O I：
10.1080/10641955.2017.1385794
中图分类号：
R71 [妇产科学];
学科分类号：
100211 ;
摘要：
Objective: Quantification of circulating fetal and total cell-free DNA (cfDNA) and soluble human leucocyte antigen (HLAG) in gestational hypertension and pre-eclampsia.Methods: Serum cfDNA were quantified in controls, pre-eclamptics, and gestational hypertensive patients using real-time qPCR. Soluble HLAG was measured by enzyme-linked immune-sorbent assay.Results: Serum fetal and total cfDNA levels were higher in pre-eclampsia compared with the controls and gestational hypertensives (p<0.001), more so in severe compared with mild-to-moderate pre-eclampsia (p<0.05). Soluble HLAG levels were lower in pre-eclamptics than controls and gestational hypertension (p<0.05).Conclusion: Circulating fetal and total cfDNA were increased, while soluble HLAG was decreased in pre-eclampsia.
引用
收藏
页码：295 / 301
页数：7
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