While large-scale motions are most energetic in the logarithmic region of a high-Reynolds-number turbulent boundary layer, they also have an influence in the inner-region. In this paper we describe an experimental investigation of manipulating the large-scale motions and reveal how this affects the turbulence and skin-friction drag. A boundary layer with a friction Reynolds number of 14 400 is controlled using a spanwise array of nine wall-normal jets operated in an on/off mode and with an exit velocity that causes the jets in cross-flow to penetrate within the log-region. Each jet is triggered in real-time with an active controller, driven by a time-resolved footprint of the large-scale motions acquired upstream. Nominally, the controller injects air into large-scale zones with positive streamwise velocity fluctuations; these zones are associated with positive wall-shear stress fluctuations. This control scheme reduced the streamwise turbulence intensity in the log-region up to a downstream distance of more than five times the boundary layer thickness, 6, from the point of actuation. The highest reduction in spectral energy more than 30%-was found for wavelengths larger than 5 delta in the log-region at 1.7 delta downstream of actuation, while scales larger than 2 delta still comprised more than 15% energy reduction in the near-wall region. In addition, a 3.2% reduction in mean skin-friction drag was achieved at 1.7 delta downstream of actuation. Our reductions of the streamwise turbulence intensity and mean skin-friction drag exceed a base line control-case, for which the jet actuators were operated with the same temporal pattern, but not synchronised with the incoming large-scale zones of positive fluctuating velocity. (C) 2017 Elsevier Inc. All rights reserved.