A Deep Insight Into the Sialotranscriptome of the Chagas Disease Vector, Panstrongylus megistus (Hemiptera: Heteroptera)

被引：25

作者：

Ribeiro, Jose M. C. ^{[1
]}

Schwarz, Alexandra ^{[2
]}

Francischetti, Ivo M. B. ^{[1
]}

机构：

[1] NIAAA, Lab Malaria & Vector Res, Rockville, MD 20852 USA

[2] Acad Sci Czech Republ, Inst Parasitol, Ctr Biol, CZ-37005 Ceske Budejovice, Czech Republic

来源：

JOURNAL OF MEDICAL ENTOMOLOGY | 2015年 / 52卷 / 03期

基金：

美国国家卫生研究院;

关键词：

Chagas disease; vector biology; salivary gland; transcriptome; medical entomology; TRIATOMA-INFESTANS; PLATELET-AGGREGATION; CATTLE TICK; SEQUENCE; SALIVA; PROTEIN; TRANSCRIPTOME; EXPRESSION; PREDICTION; INHIBITOR;

D O I：

10.1093/jme/tjv023

中图分类号：

Q96 [昆虫学];

学科分类号：

摘要：

Saliva of blood-sucking arthropods contains a complex cocktail of pharmacologically active compounds that assists feeding by counteracting their hosts' hemostatic and inflammatory reactions. Panstrongylus megistus (Burmeister) is an important vector of Chagas disease in South America, but despite its importance there is only one salivary protein sequence publicly deposited in GenBank. In the present work, we used Illumina technology to disclose and publicly deposit 3,703 coding sequences obtained from the assembly of >70 million reads. These sequences should assist proteomic experiments aimed at identifying pharmacologically active proteins and immunological markers of vector exposure.

引用

页码：351 / 358

页数：8

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