ECCO Topical Review: Refractory Inflammatory Bowel Disease (Publication with Expression of Concern)

被引：39

作者：

Raine, Tim ^{[1
]}

Verstockt, Bram ^{[2
,3
]}

Kopylov, Uri ^{[4
,5
]}

Karmiris, Konstantinos ^{[6
]}

Goldberg, Rimma ^{[7
,8
]}

Atreya, Raja ^{[9
]}

Burisch, Johan ^{[10
]}

Burke, John ^{[11
]}

Ellul, Pierre ^{[12
]}

Hedin, Charlotte ^{[13
,14
]}

Holubar, Stefan D. ^{[15
]}

Katsanos, Konstantinos ^{[16
,17
]}

Lobaton, Triana ^{[18
]}

Schmidt, Carsten ^{[19
]}

Cullen, Garret ^{[20
]}

机构：

[1] Cambridge Univ Hosp NHS Fdn Trust, Addenbrookes Hosp, Dept Gastroenterol, Cambridge, England

[2] Univ Hosp Leuven, Dept Gastroenterol & Hepatol, KU Leuven, Leuven, Belgium

[3] Katholieke Univ Leuven, Dept Chron Dis & Metab, TARGID IBD, Leuven, Belgium

[4] Sheba Med Ctr, Dept Gastroenterol, Ramat Gan, Israel

[5] Tel Aviv Univ, Sackler Sch Med, Tel Aviv, Israel

[6] Venizeleio Gen Hosp, Dept Gastroenterol, Iraklion, Greece

[7] Monash Univ, Monash Hlth, Dept Gastroenterol, Melbourne, Vic, Australia

[8] Monash Univ, Sch Clin Sci, Melbourne, Vic, Australia

[9] Univ Erlangen Nurnberg, Dept Med 1, Erlangen, Germany

[10] Univ Copenhagen, Hvidovre Hosp, Med Div, Gastrounit, Copenhagen, Denmark

[11] Beaumont Hosp, Colorectal & Gen Surg, Dublin, Ireland

[12] Mater Dei Hosp, Dept Med, Div Gastroenterol, Msida, Malta

[13] Karolinska Inst, Dept Med Solna, Stockholm, Sweden

[14] Karolinska Univ Hosp, Dept Gastroenterol Dermatovenereol & Rheumatol, Gastroenterol Unit, Stockholm, Sweden

[15] Cleveland Clin, Dept Colon & Rectal Surg, Cleveland, OH 44106 USA

[16] Univ Ioannina, Dept Gastroenterol & Hepatol, Ioannina, Greece

[17] Med Sch Ioannina, Ioannina, Greece

[18] Ghent Univ Hosp, Dept Gastroenterol, Ghent, Belgium

[19] Friedrich Schiller Univ, Med Fac, Jena, Germany

[20] Univ Coll Dublin, Ctr Colorectal Dis, Gastroenterol, St Vincents Univ Hosp & Sch Med, Dublin, Ireland

来源：

JOURNAL OF CROHNS & COLITIS | 2021年 / 15卷 / 10期

关键词：

Inflammatory bowel disease; Crohn's disease; ulcerative colitis; refractory; unlicensed medication; FECAL MICROBIOTA TRANSPLANTATION; ACTIVE ULCERATIVE-COLITIS; CYCLOPHOSPHAMIDE PULSE THERAPY; STEM-CELL TRANSPLANTATION; LUMINAL CROHNS-DISEASE; ANTI-TNF THERAPY; GRANULOCYTE/MONOCYTE ADSORPTIVE APHERESIS; COMPLEX PERIANAL FISTULAS; HYPERBARIC-OXYGEN THERAPY; MESENCHYMAL STROMAL CELLS;

D O I：

10.1093/ecco-jcc/jjab112

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Inflammatory bowel disease is a chronic disease with variable degrees of extent, severity, and activity. A proportion of patients will have disease that is refractory to licensed therapies, resulting in significant impairment in quality of life. The treatment of these patients involves a systematic approach by the entire multidisciplinary team, with particular consideration given to medical options including unlicensed therapies, surgical interventions, and dietetic and psychological support. The purpose of this review is to guide clinicians through this process and provide an accurate summary of the available evidence for different strategies.

引用

页码：1605 / 1620

页数：16

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