EXPLORING THE MECHANISM OF ANTI-INFLAMMATORY ACTIVITY OF PHYTO-STABILIZED SILVER NANORODS

In the present study, the anti-inflammatory activity of the phyto-stabilized silver nanorods has been investigated. We have already optimized the synthesis of silver nanorods using germinated fenugreek seed extract and reported its anticancer activity in skin cancer cell lines. Inflammation was induced in skin cell lines using lipopolysaccharides and thereafter the anti-inflammatory activity of silver nanorods was analysed by measuring the protein and mRNA expression of interleukins (IL-1, IL-6) and macrophage chemoattractant protein-1 (MCP-1). Our results revealed that silver nanorods could attenuate LPS-induced inflammation by inhibiting the expression of IL-1, IL-6 and MCP-1. Our results suggest that the phyto-stabilized silver nanorods may be used in the prevention of skin diseases associated with inflammation. The anti-inflammatory activity of silver nanorods might be due to its diminished size, and the phytochemicals of germinated fenugreek seeds capped on the surface of the nanoparticles. As most of the diseases including cancer are associated with inflammation, the silver nanorod is expected to emerge as an effective biomedical cum pharmacological candidate.