Venous thromboembolism in medical outpatients - a cross-sectional survey of risk assessment and prophylaxis

被引:6
作者
Lawall, Holger [2 ]
Matthiessen, Andreas
Hohmann, Volker [3 ]
Bramlage, Peter [4 ]
Haas, Sylvia [5 ]
Schellong, Sebastian [1 ]
机构
[1] Krankenhaus Dresden Friedrichstadt, Med Clin 2, Dresden, Germany
[2] Klinikum Karlsbad Langensteinbach, Karlsbad, Germany
[3] Sanofi Aventis Deutschland GmbH, Med Affairs, Berlin, Germany
[4] Inst Cardiovasc Pharmacol & Epidemiol, Mahlow, Germany
[5] Tech Univ Munich, Inst Expt Onkol & Therapieforsch, Munich, Germany
关键词
Venous thromboembolism; dispositional risk; expositional risk; enoxaparin; scorecard; risk assessment; DEEP-VEIN THROMBOSIS; PULMONARY-EMBOLISM; NONSURGICAL PATIENTS; PREVENTION; ENDORSE; EPIDEMIOLOGY; IMPACT; VTE;
D O I
10.1160/TH10-03-0191
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
The degree of thromboprophylaxis in medical outpatients is low despite a substantial risk for venous thromboembolism (VTE). This may be attributable to difficulties in assessing risk. Assessment tools like the Haas' scorecard aid in determining the need for thromboprophylaxis. We aimed at evaluating how the use of this tool may aid physicians in appropriately using anticoagulants. This was an epidemiological, cross-sectional survey of acute medically ill patients with limited mobility treated by general practitioners and internists. Risk assessment for VTE by the treating physician was compared to calculated risk. Of 8,123 patients evaluated between August 2006 and April 2008, 7,271 fulfilled the in- and exclusion criteria. Mean age was 69.4 +/- 13.6 years, and 45.2% were male. Of these 82.8% were high risk based on their acute medical condition, 37.9% based on their underlying chronic condition. Immobilisation, heart failure, pneumonia, age, obesity, and major varicosis were the most frequently encountered risk factors. The agreement between the Haas' scorecard and physician indicated risk was high. At least 94.1% of patients with high risk received adequate anticoagulation mostly as low molecular weight heparins for a mean duration of 15.1 +/- 30.5 days. There is a substantial risk for VTE in medical outpatients. Using a simple structured scorecard resulted in an overall appropriate risk assessment and high degree of anticoagulation. The scorecard may provide a tool to improve the overall awareness for VTE risk in medical outpatients, substantially improving the degree of prophylaxis in a patient population with largely underestimated risk.
引用
收藏
页码:190 / 196
页数:7
相关论文
共 29 条
  • [1] A POPULATION-BASED PERSPECTIVE OF THE HOSPITAL INCIDENCE AND CASE-FATALITY RATES OF DEEP-VEIN THROMBOSIS AND PULMONARY-EMBOLISM - THE WORCESTER DVT STUDY
    ANDERSON, FA
    WHEELER, HB
    GOLDBERG, RJ
    HOSMER, DW
    PATWARDHAN, NA
    JOVANOVIC, B
    FORCIER, A
    DALEN, JE
    [J]. ARCHIVES OF INTERNAL MEDICINE, 1991, 151 (05) : 933 - 938
  • [2] Estimated annual numbers of US acute-care hospital patients at risk for venous thromboembolism
    Anderson, Frederick A., Jr.
    Zayaruzny, Maxim
    Helt, John A.
    Fidan, Dogan
    Cohen, Alexander T.
    [J]. AMERICAN JOURNAL OF HEMATOLOGY, 2007, 82 (09) : 777 - 782
  • [3] Impact of gender on the clinical presentation and diagnosis of deep-vein thrombosis
    Bauersachs, Rupert M.
    Riess, Hanno
    Hach-Wunderle, Viola
    Gerlach, Horst
    Carnarius, Heike
    Eberle, Sonja
    Rabe, Eberhard
    Schellong, Sebastian M.
    [J]. THROMBOSIS AND HAEMOSTASIS, 2010, 103 (04) : 710 - 717
  • [4] Venous thromboembolism risk and prophylaxis in hospitalised medically ill patients The ENDORSE Global Survey
    Bergmann, Jean-Francois
    Cohen, Alexander T.
    Tapson, Victor F.
    Goldhaber, Samuel Z.
    Kakkar, Ajay K.
    Deslandes, Bruno
    Huang, Wei
    Anderson, Frederick A., Jr.
    Cherfi, Lyes
    Ammour, Dehbia
    Bentakouk, Cherif
    Bourenane, Razika
    Grainat, Nadia
    Maarouf, Abderahmane
    Sissaoui, Abdelhak
    Gallus, Alexander
    Ayyar, Venkatraman
    Crimmins, Denis
    Gan, Eng
    McRae, Simon
    Seldon, Michael
    Singh, Bhuwan
    Siddiqui, F. M.
    Moula, Kaniz
    Nawaz, Taimor
    Nazimuddin, Khwaja
    Rahman, Saiyeedur
    Sarker, Shyamal
    Rocha, Ana
    Brandao, Carlos
    Costa, Jose
    Macedo, Alex
    Marino, Roberto
    Menezes, Paulo
    Oigman, Wille
    Paiva, Marcelo
    Pantoja, Joao
    Rocha, Ana
    Schramm, Edgar
    Tandeitnik, Liane
    Timi, Jorge
    Staikov, Ivan
    Benov, Haralambi
    Borisov, Stefan Dimitrov
    Lalov, Anton
    Mirazchijski, Boyko
    Postadziyan, Arman
    Sokolov, Krassimir
    Statelov, Evgenii
    Stefanov, Chavdar
    [J]. THROMBOSIS AND HAEMOSTASIS, 2010, 103 (04) : 736 - 748
  • [5] Effective risk stratification of surgical and nonsurgical patients for venous thromboembolic disease
    Caprini, JA
    Arcelus, JI
    Reyna, JJ
    [J]. SEMINARS IN HEMATOLOGY, 2001, 38 (02) : 12 - 19
  • [6] Venous thromboembolism risk and prophylaxis in the acute hospital care setting (ENDORSE study): a multinational cross-sectional study
    Cohen, Alexander T.
    Tapson, Victor F.
    Bergmann, Jean-Francois
    Goldhaber, Samuel Z.
    Kakkar, Ajay K.
    Deslandes, Bruno
    Huang, Wei
    Zayaruzny, Maksim
    Emery, Leigh
    Anderson, Frederick A., Jr.
    [J]. LANCET, 2008, 371 (9610) : 387 - 394
  • [7] Venous thromboembolism (VTE) in Europe - The number of VTE events and associated morbidity and mortality
    Cohen, Alexander T.
    Agnelli, Giancarlo
    Anderson, Frederick A.
    Arcelus, Juan I.
    Bergqvist, David
    Brecht, Josef G.
    Greer, Ian A.
    Heit, John A.
    Hutchinson, Julia L.
    Kakkar, Ajay K.
    Mottier, Dominique
    Oger, Emmanuel
    Samama, Meyer-Michel
    Spannagl, Michael
    [J]. THROMBOSIS AND HAEMOSTASIS, 2007, 98 (04) : 756 - 764
  • [8] Assessment of venous thromboembolism risk and the benefits of thromboprophylaxis in medical patients
    Cohen, AT
    Alikhan, R
    Arcelus, JI
    Bergmann, JF
    Haass, S
    Merli, G
    Spyropoulos, AC
    Tapson, VF
    Turpie, AGG
    [J]. THROMBOSIS AND HAEMOSTASIS, 2005, 94 (04) : 750 - 759
  • [9] Prevention of venous thromboembolism
    Geerts, William H.
    Bergqvist, David
    Pineo, Graham F.
    Heit, John A.
    Samama, Charles M.
    Lassen, Michael R.
    Colwell, Clifford W.
    [J]. CHEST, 2008, 133 (06) : 381S - 453S
  • [10] Prevention of deep vein thrombosis and pulmonary embolism
    Goldhaber, SZ
    Fanikos, J
    [J]. CIRCULATION, 2004, 110 (16) : E445 - E447