Alcohol preference and consumption are controlled by the caudal linear nucleus in alcohol-preferring rats

被引:8
|
作者
Dudek, Mateusz [1 ]
Hyytia, Petri [1 ]
机构
[1] Univ Helsinki, Fac Med, Dept Pharmacol, POB 63, FIN-00014 Helsinki, Finland
基金
芬兰科学院;
关键词
alcohol preferring rats; alcohol reward; GABA; magnetic resonance imaging; manganese; VENTRAL TEGMENTAL AREA; ANIMAL-MODELS; ANA RATS; MIDBRAIN; SYSTEMS; BRAIN; ENDOMORPHIN-1; NEUROBIOLOGY; INNERVATION; PROJECTIONS;
D O I
10.1111/ejn.13245
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
The neuroanatomical and neurochemical basis of alcohol drinking has been extensively studied, but the neural circuitry mediating alcohol reinforcement has not been fully delineated. In the present experiments, we used both neuroimaging and pharmacological tools to identify neural systems associated with alcohol preference and high voluntary alcohol drinking in alcohol-preferring AA (Alko Alcohol) rats. First, we compared the basal brain activity of AA rats with that of heterogeneous Wistar rats with manganese-enhanced magnetic resonance imaging (MEMRI). Briefly, alcohol-naive rats were implanted with subcutaneous osmotic minipumps delivering 120mg/kg MnCl2 over a 7-day period, and were then imaged using a three-dimensional rapid acquisition-relaxation enhanced pulse sequence. MEMRI analysis revealed that the most conspicuous subcortical activation difference was located in the caudal linear nucleus of raphe (CLi), with AA rats displaying significantly lower T1 signal in this region compared to Wistar rats. However, following long-term alcohol drinking, CLi activity was increased in AA rats. In the second experiment, the CLi was targeted with pharmacological tools. AA rats trained to drink 10% alcohol during 2-h sessions were implanted with guide cannulas aimed at the CLi and were given injections of the GABA(A) receptor agonist muscimol into the CLi before drinking sessions. Muscimol dose-dependently increased alcohol drinking, and co-administration of the gamma aminobutyric acid (GABA)(A) antagonist bicuculline blocked muscimol's effect. These findings suggest that the mediocaudal region of the ventral tegmental area, particularly the CLi, is important for the propensity for high alcohol drinking and controls alcohol reward via GABAergic transmission.
引用
收藏
页码:1440 / 1448
页数:9
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