An Overview on Synthesis and Biological Activity of Chalcone Derived Pyrazolines

被引：19

作者：

Tiwari, Aditi ^{[1
]}

Bendi, Anjaneyulu ^{[1
]}

Bhathiwal, Anirudh Singh ^{[1
]}

机构：

[1] Shree Guru Gobind Singh Tricentenary Univ, Fac Sci, Dept Chem, Gurugram 122505, Haryana, India

来源：

CHEMISTRYSELECT | 2021年 / 6卷 / 45期

关键词：

Biological Activities; Chalcones; Hydrazines; Pharmaceutical Activities; and Pyrazolines; MICROWAVE-ASSISTED SYNTHESIS; 1,3,5-TRISUBSTITUTED PYRAZOLINES; ANTIMICROBIAL ACTIVITY; MOLECULAR DOCKING; PHARMACOLOGICAL EVALUATION; PIPERIDYL-THIENYL; BIS-CHALCONES; DERIVATIVES; ANTICANCER; BEARING;

D O I：

10.1002/slct.202103779

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Chalcones are alpha, beta unsaturated aromatic ketones having enone moiety and exhibit a wide array of pharmaceutical and biological activities. Chalcones possess a wide range of biological activities such as anticancer, antituberculosis, antidiabetic, antioxidant, anti-inflammatory, antimicrobial, and antimalarial. Nitrogen-containing heterocyclic compounds are an extremely important class of organic compounds with a broad spectrum of pharmaceutical activities. Pyrazolines are N- heterocyclic compounds that exhibit a wide range of pharmaceutical activities and are synthesized from chalcone with enhanced biological activity. The present study summarizes the chemistry of various chalcone-based pyrazolines and their derivatives with the available data till 2021.

引用

页码：12757 / 12795

页数：39

共 122 条

[51] Design, Synthesis, and In Vitro Antioxidant Activity of 1,3,5-Trisubstituted-2-pyrazolines Derivatives [J].

Jagadish, P. C. ;

Soni, Neeraj ;

Verma, Amita .

JOURNAL OF CHEMISTRY, 2013, 2013

[52] Pyrazoline based MAO inhibitors: Synthesis, biological evaluation and SAR studies [J].

Jagrat, Monika ;

Behera, Jagannath ;

Yabanoglu, Samiye ;

Ercan, Ayse ;

Ucar, Gulberk ;

Sinha, Barij Nayan ;

Sankaran, Vadivelan ;

Basu, Arijit ;

Jayaprakash, Venkatesan .

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2011, 21 (14) :4296-4300

[53] Potential pharmacological uses of chalcones: a patent review (from June 2011-2014) [J].

Joao Matos, Maria ;

Vazquez-Rodriguez, Saleta ;

Uriarte, Eugenio ;

Santana, Lourdes .

EXPERT OPINION ON THERAPEUTIC PATENTS, 2015, 25 (03) :351-366

[54]

Joshi V. D., 2012, International Journal of ChemTech Research, V4, P971

[55]

Kalirajan R., 2009, INT J CHEM TECH RSEA, V1, P27

[56] Synthesis and Evaluation of New Pyrazoline Derivatives as Potential Anticancer Agents [J].

Karabacak, Muhammed ;

Altintop, Mehlika Dilek ;

Ciftci, Halil Ibrahim ;

Koga, Ryoko ;

Otsuka, Masami ;

Fujita, Mikako ;

Ozdemir, Ahmet .

MOLECULES, 2015, 20 (10) :19066-19084

[57]

Karthikeyan C, 2015, RECENT PAT ANTI-CANC, V10, P97

[58]

Khan A.M.A., 2011, J HETEROCYCLIC CHEM, V49, P1259

[59] Multi-Step Synthesis, Physicochemical investigation and optical properties of pyrazoline derivative: A Donor-π-Acceptor chromophore [J].

Khan, Salman A. ;

Ullah, Qasim ;

Syed, Salahuddin ;

Alimuddin ;

Almalki, Abdulraheem S. A. ;

Obaid, Rami J. ;

Alsharif, Meshari A. ;

Alfaifi, S. Y. ;

Kumar, Sanjay .

JOURNAL OF MOLECULAR STRUCTURE, 2021, 1227

[60] Microwave-assisted Synthesis, Characterization, and Density Functional Theory Study of Biologically Active Ferrocenyl Bis-pyrazoline and Bis-pyrimidine as Organometallic Macromolecules [J].

Khan, Salman A. ;

Asiri, Abdullah M. ;

Zayed, Mohie E. M. ;

Parveen, Humaira ;

Aqlan, Faisal M. S. ;

Sharma, Kamlesh .

JOURNAL OF HETEROCYCLIC CHEMISTRY, 2019, 56 (01) :312-318

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