An Overview on Synthesis and Biological Activity of Chalcone Derived Pyrazolines

被引：19

作者：

Tiwari, Aditi ^{[1
]}

Bendi, Anjaneyulu ^{[1
]}

Bhathiwal, Anirudh Singh ^{[1
]}

机构：

[1] Shree Guru Gobind Singh Tricentenary Univ, Fac Sci, Dept Chem, Gurugram 122505, Haryana, India

来源：

CHEMISTRYSELECT | 2021年 / 6卷 / 45期

关键词：

Biological Activities; Chalcones; Hydrazines; Pharmaceutical Activities; and Pyrazolines; MICROWAVE-ASSISTED SYNTHESIS; 1,3,5-TRISUBSTITUTED PYRAZOLINES; ANTIMICROBIAL ACTIVITY; MOLECULAR DOCKING; PHARMACOLOGICAL EVALUATION; PIPERIDYL-THIENYL; BIS-CHALCONES; DERIVATIVES; ANTICANCER; BEARING;

D O I：

10.1002/slct.202103779

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Chalcones are alpha, beta unsaturated aromatic ketones having enone moiety and exhibit a wide array of pharmaceutical and biological activities. Chalcones possess a wide range of biological activities such as anticancer, antituberculosis, antidiabetic, antioxidant, anti-inflammatory, antimicrobial, and antimalarial. Nitrogen-containing heterocyclic compounds are an extremely important class of organic compounds with a broad spectrum of pharmaceutical activities. Pyrazolines are N- heterocyclic compounds that exhibit a wide range of pharmaceutical activities and are synthesized from chalcone with enhanced biological activity. The present study summarizes the chemistry of various chalcone-based pyrazolines and their derivatives with the available data till 2021.

引用

页码：12757 / 12795

页数：39

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