The Unsolved Problem of How Cells Sense Micron-Scale Curvature

被引:27
作者
Cannon, Kevin S. [1 ]
Woods, Benjamin L. [1 ]
Gladfelter, Amy S. [1 ]
机构
[1] Univ North Carolina Chapel Hill, Dept Biol, Chapel Hill, NC 27599 USA
基金
美国国家科学基金会;
关键词
ACYL-CHAIN-LENGTH; SACCHAROMYCES-CEREVISIAE; BUDDING YEAST; MEMBRANE CURVATURE; MORPHOGENESIS CHECKPOINT; BACILLUS-SUBTILIS; PLASMA-MEMBRANE; LIPID DROPLETS; TYROSINE PHOSPHORYLATION; ENDOPLASMIC-RETICULUM;
D O I
10.1016/j.tibs.2017.10.001
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Membrane curvature is a fundamental feature of cells and their organelles. Much of what we know about how cells sense curved surfaces comes from studies examining nanometer-sized molecules on nanometer-scale curvatures. We are only just beginning to understand how cells recognize curved topologies at the micron scale. In this review, we provide the reader with an overview of our current understanding of how cells sense and respond to micron-scale membrane curvature.
引用
收藏
页码:961 / 976
页数:16
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