A Mathematical Approach to Study the Bending Behavior of the Primary Cilium

被引：0

作者：

Herzog, F. A. ^{[1
]}

Geraedts, J. ^{[1
]}

Hoey, D. ^{[1
]}

Jacobs, C. R. ^{[1
]}

机构：

[1] Columbia Univ City New York, New York, NY USA

来源：

2010 IEEE 36TH ANNUAL NORTHEAST BIOENGINEERING CONFERENCE | 2010年

关键词：

FLOW; CELLS;

D O I：

暂无

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 ;

摘要：

The primary cilium, a hair-like projection from the cellular membrane, is involved in fluid flow sensing. In this study, the primary cilium is modeled as a thin beam undergoing large deflection due to fluid drag forces. For the first time, the bending response is analyzed with a model combining large angle rotations with the assumption of a linear drag force along the ciliary length. The model is applied on published pictures of bent cilia. Incorporating a linear drag force and allowing for a basal tilt is an important step towards a more realistic mechanical model of the primary cilium and towards more accurate values of its flexural rigidity. The model will be a useful tool to study the mechanical behavior of the primary cilium and will eventually lead to new insight in the poorly understood mechanisms of mechanotransduction.

引用

页数：2

共 7 条

[1]

Holden J. T., 1972, International Journal of Solids and Structures, V8, P1051, DOI 10.1016/0020-7683(72)90069-8

[2] Effect of flow and stretch on the [Ca2+]i response of principal and intercalated cells in cortical collecting duct [J].