Multifunctional Gd-CuS loaded UCST polymeric micelles for MR/PA imaging-guided chemo-photothermal tumor treatment

被引：14

作者：

Du, Yan ^{[1
]}

Liu, Di ^{[1
]}

Sun, Mingchen ^{[1
]}

Shu, Gaofeng ^{[2
]}

Qi, Jing ^{[1
]}

You, Yuchan ^{[1
]}

Xu, Yiting ^{[1
]}

Fan, Kai ^{[2
]}

Xu, Xiaoling ^{[1
]}

Jin, Feiyang ^{[1
]}

Wang, Jun ^{[1
]}

Shen, Qiying ^{[1
]}

Zhu, Luwen ^{[1
]}

Ying, Xiaoying ^{[1
]}

Ji, Jiansong ^{[2
]}

Wu, Liming ^{[3
]}

Liu, Daren ^{[4
]}

Du, Yongzhong ^{[1
]}

机构：

[1] Zhejiang Univ, Coll Pharmaceut Sci, Inst Pharmaceut, Hangzhou 310058, Peoples R China

[2] Zhejiang Univ, Sch Med, Key Lab Imaging Diag & Minimally Invas Intervent, Lishui Hosp, Lishui 323000, Peoples R China

[3] Zhejiang Univ, Affiliated Hosp 1, Dept Hepatobiliary & Pancreat Surg, Sch Med, Hangzhou 310003, Peoples R China

[4] Zhejiang Univ, Affiliated Hosp 2, Dept Gen Surg, Sch Med, Hangzhou 310009, Peoples R China

来源：

NANO RESEARCH | 2022年 / 15卷 / 03期

关键词：

hepatocellular carcinoma; upper critical solution temperature (UCST); Gd-CuS nanoparticles; chemo-photothermal therapy; magnetic resonance (MR); photoacoustic (PA) dual-mode imaging; NANOPARTICLES; THERAPY; MRI; DOXORUBICIN;

D O I：

10.1007/s12274-021-3812-2

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

Hepatocellular carcinoma (HCC) is a life-threatening disease for which there is no effective treatment currently. Novel theranostics simultaneously having excellent imaging and therapeutic functions are highly desired in cancer therapy. Herein, we develop the sialic acid (SA) modified polymeric micelles at an upper critical solution temperature (UCST) of 43 degrees C (sialic acid-polyethylene glycol)-poly(acrylamide-co-acrylonitrile), SA-PEG-p(AAm-co-AN)), which further encapsulated with doxorubicin (DOX) and Gd-CuS nanoparticles (Gd-CuS NPs) for chemo-photothermal treatment of HCC guided by magnetic resonance (MR)/photoacoustic (PA) dual-mode imaging. The resultant SA-PEG-p(AAm-co-AN)/DOX/Gd-CuS (SPDG) had an excellent photothermal conversion efficiency, enabling SPDG with an instantaneous release behavior of DOX under near-infrared (NIR) irradiation. This study also revealed that SPDG could actively target to HCC, which was due to that SA had a high affinity with E-selectin overexpressed at the tumor site. Moreover, benefiting from the HCC-targeted ability and NIR light-controlled on-demand delivery of DOX, SPDG showed a superior potential in MR/PA dual-mode imaging-guided chemo-photothermal treatment. Overall, our study reveals that the designed SPDG may be used as an ideal multifunctional nanoplatform for cancer theranostics.

引用

页码：2288 / 2299

页数：12

共 44 条

[11] E-selectin-targeted Sialic Acid-PEG-dexamethasone Micelles for Enhanced Anti-Inflammatory Efficacy for Acute Kidney Injury [J].

Hu, Jing-Bo ;

Kang, Xu-Qi ;

Liang, Jing ;

Wang, Xiao-Juan ;

Xu, Xiao-Ling ;

Yang, Ping ;

Ying, Xiao-Ying ;

Jiang, Sai-Ping ;

Du, Yong-Zhong .

THERANOSTICS, 2017, 7 (08) :2204-2219

[12] Copper Sulfide Nanoparticles with Phospholipid-PEG Coating for In Vivo Near-Infrared Photothermal Cancer Therapy [J].

Huang, Yizhuan ;

Lai, Yulian ;

Shi, Saige ;

Hao, Shufang ;

Wei, Jingping ;

Chen, Xiaolan .

CHEMISTRY-AN ASIAN JOURNAL, 2015, 10 (02) :370-376

[13] Ultrasound-triggered disruption and self-healing of reversibly cross-linked hydrogels for drug delivery and enhanced chemotherapy [J].

Huebsch, Nathaniel ;

Kearney, Cathal J. ;

Zhao, Xuanhe ;

Kim, Jaeyun ;

Cezar, Christine A. ;

Suo, Zhigang ;

Mooney, David J. .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2014, 111 (27) :9762-9767

[14] Systems model of signaling identifies a molecular basis set for cytokine-induced apoptosis [J].

Janes, KA ;

Albeck, JG ;

Gaudet, S ;

Sorger, PK ;

Lauffenburger, DA ;

Yaffe, MB .

SCIENCE, 2005, 310 (5754) :1646-1653

[15] 'Two is better than one'-probes for dual-modality molecular imaging [J].

Jennings, Lucy E. ;

Long, Nicholas J. .

CHEMICAL COMMUNICATIONS, 2009, (24) :3511-3524

[16] Complete regression of local cancer using temperature-sensitive liposomes combined with ultrasound-mediated hyperthermia [J].

Kheirolomoom, Azadeh ;

Lai, Chun-Yen ;

Tam, Sarah M. ;

Mahakian, Lisa M. ;

Ingham, Elizabeth S. ;

Watson, Katherine D. ;

Ferrara, Katherine W. .

JOURNAL OF CONTROLLED RELEASE, 2013, 172 (01) :266-273

[17] A brain tumor molecular imaging strategy using a new triple-modality MRI-photoacoustic-Raman nanoparticle [J].

Kircher, Moritz F. ;

de la Zerda, Adam ;

Jokerst, Jesse V. ;

Zavaleta, Cristina L. ;

Kempen, Paul J. ;

Mittra, Erik ;

Pitter, Ken ;

Huang, Ruimin ;

Campos, Carl ;

Habte, Frezghi ;

Sinclair, Robert ;

Brennan, Cameron W. ;

Mellinghoff, Ingo K. ;

Holland, Eric C. ;

Gambhir, Sanjiv S. .

NATURE MEDICINE, 2012, 18 (05) :829-U235

[18] Mild microwave activated, chemo-thermal combinational tumor therapy based on a targeted, thermal-sensitive and magnetic micelle [J].

Li, Wei-Shuo ;

Wang, Xiao-Juan ;

Zhang, Shuo ;

Hu, Jing-Bo ;

Du, Yang-Long ;

Kang, Xu-Qi ;

Xu, Xiao-Ling ;

Ying, Xiao-Ying ;

You, Jian ;

Du, Yong-Zhong .

BIOMATERIALS, 2017, 131 :36-46

[19] Corrigendum: Antitumor Drug Delivery Modulated by A Polymeric Micelle with an Upper Critical Solution Temperature (vol 54, pg 3126, 2015) [J].

Li, Weishuo ;

Huang, Liwen ;

Ying, Xiaoying ;

Jian, You ;

Hong, Yuan ;

Hu, Fuqiang ;

Du, Yongzhong .

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2015, 54 (23) :6671-6671

[20] Safety and feasibility of ultrasound-triggered targeted drug delivery of doxorubicin from thermosensitive liposomes in liver tumours (TARDOX): a single-centre, open-label, phase 1 trial [J].

Lyon, Paul C. ;

Gray, Michael D. ;

Mannaris, Christophoros ;

Folkes, Lisa K. ;

Stratford, Michael ;

Campo, Leticia ;

Chung, Daniel Y. F. ;

Scott, Shaun ;

Anderson, Mark ;

Goldin, Robert ;

Carlisle, Robert ;

Wu, Feng ;

Middleton, Mark R. ;

Gleeson, Fergus V. ;

Coussios, Constantin C. .

LANCET ONCOLOGY, 2018, 19 (08) :1027-1039

← 1 2 3 4 5 →