The network as the target

被引：8

作者：

Baggs, Julie E. ^{[1
]}

Hughes, Michael E. ^{[1
]}

Hogenesch, John B. ^{[1
]}

机构：

[1] Univ Penn, Sch Med, Inst Translat Med & Therapeut, Philadelphia, PA 19104 USA

来源：

WILEY INTERDISCIPLINARY REVIEWS-SYSTEMS BIOLOGY AND MEDICINE | 2010年 / 2卷 / 02期

关键词：

PROTEIN-PROTEIN INTERACTIONS; C-ELEGANS; SACCHAROMYCES-CEREVISIAE; INTERACTOME NETWORK; EARLY EMBRYOGENESIS; RNA INTERFERENCE; GENOME; MAP; YEAST; MOLECULES;

D O I：

10.1002/wsbm.57

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

The conventional target centric model of drug discovery is pinned under the weight of prior success and the traditional problems of safety and efficacy for new molecules. An alternative to target centric drug development is to shift focus to the pathways that mediate both biology and pathophysiology. This method has the advantage of not requiring a priori knowledge of the small molecule target, but also comes with it several challenges including target determination. We suggest extending this notion more broadly across the drug discovery process using quantitative network structure-activity relationships (QNSAR), and discuss the steps necessary to test the hypothesis that systems biology approaches can be used to improve the drug discovery process. (C) 2009 John Wiley & Sons, Inc. WIREs Syst Biol Med 2010 2 127-133

引用

页码：127 / 133

页数：7

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