Effect of oncom extract on the level of estrogen hormone of productive white rats

被引:1
作者
Laksmi, Desak Nyoman Dewi Indira [1 ]
Setiasih, Ni Luh Eka [2 ]
Trilaksana, I. Gusti Ngurah Bagus [1 ]
机构
[1] Univ Udayana, Fac Vet Med, Lab Vet Reprod, PB Sudirman St, Denpasar, Bali, Indonesia
[2] Univ Udayana, Fac Vet Med, Lab Vet Histol, Bali, Indonesia
关键词
oncom; isoflavones; estrogen levels; white rats; RECEPTOR-ALPHA;
D O I
10.15562/bmj.v10i2.2504
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Introduction: Oncom is a processed soybean that contains isoflavone compounds. The types of isoflavones found in soybeans and their dairy products are daidzein and genistein which have an estrogenic effect on animals' reproductive performance. This study aimed to determine the effect of oncom extract on productive age white rats (Rattus norvegicus) estrogen levels. Methods: This research is an experimental study with a randomized posttest control group design. We used 21 samples divided into three groups. First group was control without being given oncom extract. The second group was given a black oncom extract dose of 0.005 g/g BB. The third group was given red oncom extract of dose 0.005 g/g body weight. Serum collection for estrogen hormone level measurement was collected on day 14 after administration of oncom extract. Data then analyzed to determine the normality and homogeneity. ANOVA test was used to compare the means between groups. P<0.05 was significant. Result: We found in the control group with the lowest estrogen level mean (16.70 +/- 0.581) than the experimental groups. The ANOVA analysis results showed that oncom extract significantly increase estrogen levels of productive age white rats (p<0.05). Conclusion: Oncom extract can increase the estrogen level in productive age white rats. However, the estrogen levels between red oncom and black oncom showed an insignificant difference.
引用
收藏
页码:559 / 561
页数:3
相关论文
共 11 条
  • [1] Cahyadi W, 2007, TEKNOLOGI DAN KHASIA
  • [2] Mechanism of estrogen action:: Lessons from the estrogen receptor-α knockout mouse
    Cooke, PS
    Buchanan, DL
    Lubahn, DB
    Cunha, GR
    [J]. BIOLOGY OF REPRODUCTION, 1998, 59 (03) : 470 - 475
  • [3] Hall JE, 2020, Guyton and Hall textbook of medical physiology
  • [4] Hanifa AN, 2018, PENGARUH EKSTRAK ONC
  • [5] Heinnermen J, 2003, PERAN ISOFLAVON UNTU
  • [6] Dissecting physiological roles of estrogen receptor α and β with potent selective ligands from structure-based design
    Hillisch, A
    Peters, O
    Kosemund, D
    Müller, G
    Walter, A
    Schneider, B
    Reddersen, G
    Elger, W
    Fritzemeier, KH
    [J]. MOLECULAR ENDOCRINOLOGY, 2004, 18 (07) : 1599 - 1609
  • [7] Johnson MH, 2018, ESSENTIAL REPROD
  • [8] Nasiroh IS, 2015, PENGARUH KOMBINASI E
  • [9] Pawiroharsono S., PROSPEK DAN MANFAAT
  • [10] Sitasiwi AJ, 2008, ANAT FISIOL, V16, P38