Elemental Sulfur-Promoted Aerobic Cyclization of Ketones and Aliphatic Amines for Synthesis of Tetrasubstituted Imidazoles

被引：43

作者：

Chen, Xiangui ^{[1
]}

Wang, Zhen ^{[1
]}

Huang, Huawen ^{[1
]}

Deng, Guo-Jun ^{[1
]}

机构：

[1] Xiangtan Univ, Coll Chem, Key Lab Green Organ Synth & Applicat Hunan Prov, Key Lab Environm Friendly Chem & Applicat,Minist, Xiangtan 411105, Peoples R China

来源：

ADVANCED SYNTHESIS & CATALYSIS | 2018年 / 360卷 / 20期

基金：

中国国家自然科学基金;

关键词：

Elemental sulfur; tetrasubstituted imidazoles; co-oxidant; metal-free; METAL-FREE CONDITIONS; ONE-POT SYNTHESIS; MULTICOMPONENT COUPLING APPROACH; C-H OXIDATION; 1,2,4,5-TETRASUBSTITUTED IMIDAZOLES; POLYSUBSTITUTED IMIDAZOLES; SUBSTITUTED IMIDAZOLES; MULTISUBSTITUTED IMIDAZOLES; FUNCTIONALIZED IMIDAZOLES; NITROGEN-HETEROCYCLES;

D O I：

10.1002/adsc.201800765

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

Elemental sulfur-promoted cyclization for the one-pot synthesis of tetra-substituted imidazoles from benzylamines and ketones is described. Elemental sulfur combined with molecular oxygen as the benign co-oxidant was found to be the key for the high efficiency of this transformation under metal-free conditions. A range of tetrasubstituted imidazoles were synthesized from simple ketones and amines with good functional group tolerance.

引用

收藏

页码：4017 / 4022

页数：6

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