Biomimetic drug-delivery systems for the management of brain diseases

被引：64

作者：

Chen, Yao-xing ^{[1
]}

Wei, Chen-xuan ^{[1
]}

Lyu, Ying-qi ^{[1
]}

Chen, Hong-zhuan ^{[1
,2
]}

Jiang, Gan ^{[1
]}

Gao, Xiao-ling ^{[1
]}

机构：

[1] Shanghai Jiao Tong Univ, Shanghai Univ Collaborat Innovat Ctr Translat Med, Sch Med, Dept Pharmacol & Chem Biol, 280 South Chongqing Rd, Shanghai 200025, Peoples R China

[2] Shanghai Univ Tradit Chinese Med, Inst Interdisciplinary Integrat Biomed Res, 1200 Cailun Rd, Shanghai 201210, Peoples R China

来源：

BIOMATERIALS SCIENCE | 2020年 / 8卷 / 04期

基金：

中国国家自然科学基金;

关键词：

MESENCHYMAL STROMAL CELLS; FOCAL CEREBRAL-ISCHEMIA; CENTRAL-NERVOUS-SYSTEM; SMALL INTERFERING RNA; GROWTH-FACTOR; GENE-THERAPY; FUNCTIONAL RECOVERY; TARGETED DELIVERY; IN-VITRO; CONJUGATED NANOPARTICLES;

D O I：

10.1039/c9bm01395d

中图分类号：

TB3 [工程材料学]; R318.08 [生物材料学];

学科分类号：

0805 ; 080501 ; 080502 ;

摘要：

Acting as a double-edged sword, the blood-brain barrier (BBB) is essential for maintaining brain homeostasis by restricting the entry of small molecules and most macromolecules from blood. However, it also largely limits the brain delivery of most drugs. Even if a drug can penetrate the BBB, its accumulation in the intracerebral pathological regions is relatively low. Thus, an optimal drug-delivery system (DDS) for the management of brain diseases needs to display BBB permeability, lesion-targeting capability, and acceptable safety. Biomimetic DDSs, developed by directly utilizing or mimicking the biological structures and processes, provide promising approaches for overcoming the barriers to brain drug delivery. The present review summarizes the biological properties and biomedical applications of the biomimetic DDSs including the cell membrane-based DDS, lipoprotein-based DDS, exosome-based DDS, virus-based DDS, protein template-based DDS and peptide template-based DDS for the management of brain diseases.

引用

页码：1073 / 1088

页数：16

共 171 条

[61] Enhanced Brain Delivery of Deferasirox-Lactoferrin Conjugates for Iron Chelation Therapy in Neurodegenerative Disorders: In Vitro and in Vivo Studies [J].