Combination of urinary fibrinogen β-chain and tyrosine-phosphorylated proteins for the detection of bladder cancer

被引：1

作者：

Giribaldi, Giuliana ^{[1
]}

Filippini, Claudia ^{[2
]}

Viberti, Clara ^{[3
]}

Khadjavi, Amina ^{[1
]}

Finesso, Nicole ^{[1
]}

Ulliers, Daniela ^{[1
]}

Turini, Stefano ^{[4
]}

Bressan, Bruno Emilio ^{[1
]}

Pecoraro, Francesca ^{[1
]}

Prato, Mauro ^{[4
]}

Allione, Alessandra ^{[3
]}

Bellis, Matteo De ^{[5
]}

Montefusco, Gabriele ^{[5
]}

Bonomessi, Giulia ^{[5
]}

Allasia, Marco ^{[5
]}

Matullo, Giuseppe ^{[3
,6
]}

Soria, Francesco ^{[5
]}

Gontero, Paolo ^{[5
]}

机构：

[1] Univ Turin, Dept Oncol, Turin, Italy

[2] Univ Turin, Dept Surg Sci, Turin, Italy

[3] Univ Turin, Dept Med Sci, Turin, Italy

[4] Univ Turin, Dept Neurosci, Turin, Italy

[5] Torino Sch Med, AOU Citta & Salute Sci, Dept Surg Sci, Div Urol, Turin, Italy

[6] AOU Citta Salute & Sci, SC Med Genet, Turin, Italy

来源：

FUTURE SCIENCE OA | 2021年 / 7卷 / 09期

关键词：

bladder cancer; fibrinogen beta-chain; tyrosine-phosphorylated proteins; urinary markers; MARKERS;

D O I：

10.2144/fsoa-2021-0060

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Aim: to evaluate the performance of urinary fibrinogen beta-chain (FBC) - either alone or associated with urinary tyrosine-phosphorylated proteins (UPY) - as bladder cancer (BCa) diagnostic biomarker. Materials & methods: 164 subjects were tested. Results: significantly different FBC and UPY levels were found between BCa patients and controls, as well as between low-grade and high-grade cancers. The diagnostic accuracy was 0.84 for FBC and 0.87 for UPY. The combination of FBC and UPY improved the accuracy to 0.91. The addition of clinical variables (age, gender, and smoking habit) to FBC and UPY into a model for BCa prediction significantly improved the accuracy to 0.99. The combination of FBC and UPY adjusted for clinical variables associates with the highest sensitivity and good specificity. Conclusion: urinary FBC and UPY could be used as biomarkers for BCa diagnosis.

引用

页数：10

共 24 条

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