Hybrid nanocapsules: Interactions of ABA block copolymers with liposomes

被引：105
作者：
Ruysschaert, T
Sonnen, AFP
Haefele, T
Meier, W
Winterhaltert, M
Fournier, D [1 ]
机构：
[1] Inst Pharmacol & Biol Struct, Grp Biotechnol Prot, F-31077 Toulouse, France
[2] Int Univ Bremen, D-28726 Bremen, Germany
[3] Univ Basel, Dept Chem Phys, CH-4056 Basel, Switzerland
来源：
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2005年 / 127卷 / 17期
关键词：
D O I：
10.1021/ja043600x
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Amphiphilic ABA triblock copolymers, such as poly(2-methyloxazoline)-block-poly(dimethylsiloxan)block-poly(2-methyloxazoline) (PMOXA-PDMS-PMOXA), form vesicular structures. Here, the interaction of these ABA molecules with lipids is investigated by electron microscopy, fluorescence spectroscopy, light scattering, and differential scanning calorimetry. Our observations suggest the formation of homogeneous mixed polymer-lipid composites, independent of preparation method, i.e. film hydration, dispersion, or detergent removal. When ABA polymersomes and liposomes are mixed, we observed monomer exchanges on a time scale of minutes. The possibility of forming mixed structures and the exchanges between preformed structures allow the combination of the properties of lipids and polymers such as stability and loading encapsulation capacity.
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收藏
页码：6242 / 6247
页数：6
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