A neural and behavioral trade-off between value and uncertainty underlies exploratory decisions in normative anxiety

被引:22
作者
Aberg, Kristoffer C. [1 ,2 ]
Toren, Ido [1 ,2 ]
Paz, Rony [1 ,2 ]
机构
[1] Weizmann Inst Sci, Azrieli Natl Inst Human Brain Imaging & Res, Rehovot, Israel
[2] Weizmann Inst Sci, Dept Brain Sci, Rehovot, Israel
基金
欧洲研究理事会;
关键词
SELF-EFFICACY; INDIVIDUAL-DIFFERENCES; INTOLERANCE; FEAR; MECHANISMS; REWARD; TRAIT; EXPLOITATION; ANTICIPATION; PERSONALITY;
D O I
10.1038/s41380-021-01363-z
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Exploration reduces uncertainty about the environment and improves the quality of future decisions, but at the cost of provisional uncertain and suboptimal outcomes. Although anxiety promotes intolerance to uncertainty, it remains unclear whether and by which mechanisms anxiety relates to exploratory decision-making. We use a dynamic three-armed-bandit task and find that higher trait-anxiety is associated with increased exploration, which in turn harms overall performance. We identify two distinct behavioral sources: first, decisions made by anxious individuals are guided toward reduction of uncertainty; and second, decisions are less guided by immediate value gains. These findings are similar in both loss and gain domains, and further demonstrate that an affective trait relates to exploration and results in an inverse-U-shaped relationship between anxiety and overall performance. Additional imaging data (fMRI) suggests that normative anxiety correlates negatively with the representation of expected-value in the dorsal-anterior-cingulate-cortex, and in contrast, positively with the representation of uncertainty in the anterior-insula. We conclude that a trade-off between value-gains and uncertainty-reduction entails maladaptive decision-making in individuals with higher normal-range anxiety.
引用
收藏
页码:1573 / 1587
页数:15
相关论文
共 108 条
[21]   Multimodel inference - understanding AIC and BIC in model selection [J].
Burnham, KP ;
Anderson, DR .
SOCIOLOGICAL METHODS & RESEARCH, 2004, 33 (02) :261-304
[22]   Into the unknown: A review and synthesis of contemporary models involving uncertainty [J].
Carleton, R. Nicholas .
JOURNAL OF ANXIETY DISORDERS, 2016, 39 :30-43
[23]   Narcissists' social pain seen only in the brain [J].
Cascio, Christopher N. ;
Konrath, Sara H. ;
Falk, Emily B. .
SOCIAL COGNITIVE AND AFFECTIVE NEUROSCIENCE, 2015, 10 (03) :335-341
[24]   Frontal Theta Reflects Uncertainty and Unexpectedness during Exploration and Exploitation [J].
Cavanagh, James F. ;
Figueroa, Christina M. ;
Cohen, Michael X. ;
Frank, Michael J. .
CEREBRAL CORTEX, 2012, 22 (11) :2575-2586
[25]   Dopaminergic modulation of the exploration/exploitation trade-off in human decision-making [J].
Chakroun, Karima ;
Mathar, David ;
Wiehler, Antonius ;
Ganzer, Florian ;
Peters, Jan .
ELIFE, 2020, 9 :1-44
[26]   The relationship between trait vulnerability and anxiety and depressive diagnoses at long-term follow-up of Generalized Anxiety Disorder [J].
Chambers, JA ;
Power, KG ;
Durham, RC .
JOURNAL OF ANXIETY DISORDERS, 2004, 18 (05) :587-607
[27]   OPTIMAL FORAGING, MARGINAL VALUE THEOREM [J].
CHARNOV, EL .
THEORETICAL POPULATION BIOLOGY, 1976, 9 (02) :129-136
[28]   Enhanced Risk Aversion, But Not Loss Aversion, in Unmedicated Pathological Anxiety [J].
Charpentier, Caroline J. ;
Aylward, Jessica ;
Roiser, Jonathan P. ;
Robinson, Oliver J. .
BIOLOGICAL PSYCHIATRY, 2017, 81 (12) :1014-1022
[29]   TEMPERAMENT, PERSONALITY, AND THE MOOD AND ANXIETY DISORDERS [J].
CLARK, LA ;
WATSON, D ;
MINEKA, S .
JOURNAL OF ABNORMAL PSYCHOLOGY, 1994, 103 (01) :103-116
[30]   Should I stay or should I go? How the human brain manages the trade-off between exploitation and exploration [J].
Cohen, Jonathan D. ;
McClure, Samuel M. ;
Yu, Angela J. .
PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES, 2007, 362 (1481) :933-942