Expression of tau reduces secretion of Aβ without altering the amyloid precursor protein content in CHOsw cells

被引：6

作者：

Zhao, Z ^{[1
]}

Ksiezak-Reding, H ^{[1
]}

Wang, J ^{[1
]}

Pasinetti, GM ^{[1
]}

机构：

[1] CUNY Mt Sinai Sch Med, Dept Psychiat, Neuroinflammat Res Labs, New York, NY 10029 USA

来源：

FEBS LETTERS | 2005年 / 579卷 / 10期

关键词：

Alzheimer's disease; tau; amyloid precursor protein; A beta peptide; secretase; insulin degrading enzyme; adenovirus;

D O I：

10.1016/j.febslet.2005.02.067

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Insoluble deposits of tau and amyloid precursor protein (APP) peptides A beta characterize Alzheimer's disease. We studied the role of tau in the metabolism of APP in cells stably expressing APP Swedish mutation (CHOsw). Transient expression of tau in CHOsw cells caused morphological changes, bundling of microtubules and perinuclear aggregation of Golgi-derived vesicles. It also reduced the secretion of A beta(1-40) and A beta(1-42) without altering the APP steady state levels. This was accompanied by a reduction in the gamma-secretase and an increase in the insulin degrading enzyme activities. Our results suggest that tau may play an inhibitory role in the amyloidogenic activity of APP. (c) 2005 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.

引用

页码：2119 / 2124

页数：6

共 18 条

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