A direct quantitative relationship between the functional properties of human and macaque V5

被引：478
作者：
Rees, G [1 ]
Friston, KJ
Koch, C
机构：
[1] CALTECH, Div Biol 139 74, Pasadena, CA 91125 USA
[2] UCL, Neurol Inst, Wellcome Dept Cognit Neurol, London WC1N 3BG, England
来源：
NATURE NEUROSCIENCE | 2000年 / 3卷 / 07期
基金：
英国惠康基金; 美国国家科学基金会;
关键词：
D O I：
10.1038/76673
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
The nature of the quantitative relationship between single-neuron recordings in monkeys and functional magnetic resonance imaging (fMRI) measurements in humans is crucial to understanding how experiments in these different species are related, yet it remains undetermined. We measured brain activity in humans attending to moving visual stimuli, using blood oxygenation level-dependent (BOLD) fMRI. Responses in Vs showed a strong and highly linear dependence on increasing strength of motion signal (coherence). These population responses in human Vs had a remarkably simple mathematical relationship to previously observed single-cell responses in macaque Vs. We provided an explicit quantitative estimate for the interspecies comparison of single-neuron activity and BOLD population responses. Our data show previously unknown dissociations between the functional properties of human Vs and other human motion-sensitive areas, thus predicting similar dissociations for the properties of single neurons in homologous areas of macaque cortex.
引用
收藏
页码：716 / 723
页数：8
相关论文
共 40 条
  • [1] SPATIOTEMPORAL ENERGY MODELS FOR THE PERCEPTION OF MOTION
    ADELSON, EH
    BERGEN, JR
    [J]. JOURNAL OF THE OPTICAL SOCIETY OF AMERICA A-OPTICS IMAGE SCIENCE AND VISION, 1985, 2 (02) : 284 - 299
  • [2] DIRECTION AND ORIENTATION SELECTIVITY OF NEURONS IN VISUAL AREA MT OF THE MACAQUE
    ALBRIGHT, TD
    [J]. JOURNAL OF NEUROPHYSIOLOGY, 1984, 52 (06) : 1106 - 1130
  • [3] COLUMNAR ORGANIZATION OF DIRECTIONALLY SELECTIVE CELLS IN VISUAL AREA MT OF THE MACAQUE
    ALBRIGHT, TD
    DESIMONE, R
    GROSS, CG
    [J]. JOURNAL OF NEUROPHYSIOLOGY, 1984, 51 (01) : 16 - 31
  • [4] CRESCENT-SHAPED CORTICAL VISUAL AREA SURROUNDING MIDDLE TEMPORAL AREA (MT) IN OWL MONKEY (AOTUS-TRIVIRGATUS)
    ALLMAN, JM
    KAAS, JH
    [J]. BRAIN RESEARCH, 1974, 81 (02) : 199 - 213
  • [5] RESPONSES OF NEURONS IN MACAQUE MT TO STOCHASTIC MOTION SIGNALS
    BRITTEN, KH
    SHADLEN, MN
    NEWSOME, WT
    MOVSHON, JA
    [J]. VISUAL NEUROSCIENCE, 1993, 10 (06) : 1157 - 1169
  • [6] Tuning bandwidths for near-threshold stimuli in area MT
    Britten, KH
    Newsome, WT
    [J]. JOURNAL OF NEUROPHYSIOLOGY, 1998, 80 (02) : 762 - 770
  • [7] BRITTEN KH, 1992, J NEUROSCI, V12, P4745
  • [8] Characterizing stimulus-response functions using nonlinear regressors in parametric fMRI experiments
    Buchel, C
    Holmes, AP
    Rees, G
    Friston, KJ
    [J]. NEUROIMAGE, 1998, 8 (02) : 140 - 148
  • [9] Nonlinear regression in parametric activation studies
    Buchel, C
    Wise, RJS
    Mummery, CJ
    Poline, JB
    Friston, KJ
    [J]. NEUROIMAGE, 1996, 4 (01) : 60 - 66
  • [10] Anterior cingulate cortex, error detection, and the online monitoring of performance
    Carter, CS
    Braver, TS
    Barch, DM
    Botvinick, MM
    Noll, D
    Cohen, JD
    [J]. SCIENCE, 1998, 280 (5364) : 747 - 749
1234